CHLORINATED ORGANIC CONTAMINANTS IN BREAST-MILK OF NEW-ZEALAND WOMEN
CHLORINATED ORGANIC CONTAMINANTS IN BREAST-MILK OF NEW-ZEALAND WOMEN
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DOI：
10.1289/ehp.94102s1211
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发表时间：
1994-01-01
影响因子：
10.4
通讯作者：
VANMAANEN, T
中科院分区：
文献类型：
--
作者：
BATES, MN;HANNAH, DJ;VANMAANEN, T
作为世界卫生组织母乳污染物合作研究的一部分，对新西兰 38 名妇女的母乳样本进行了有机氯农药、多氯联苯 (PCB)、多氯二苯并对二恶英 (PCDD) 和多氯二苯并呋喃 (PCDF) 分析。这些女性是从新西兰北岛和南岛的两个城市地区（奥克兰和基督城）和两个农村地区（北岛和北坎特伯雷）招募的。已发现母乳中污染物浓度的最佳预测因素是母亲的年龄。六氯苯、狄氏剂和 pp-DDE 存在地区差异，反映了历史使用模式。当以全脂牛奶为基础计算污染物浓度时，发现多种 PCB、PCDD 和 PCDF 存在城乡差异。然而，这些差异可能归因于城市和农村母亲母乳脂肪浓度的差异。城市母亲的母乳脂肪比农村母亲多约50%。有证据表明，婴儿的母乳消耗量受热量摄入的调节。牛奶的几乎所有热量含量都在脂肪部分中。这表明以全脂奶为基础计算的母乳污染物水平不一定反映婴儿接触这些污染物的相对水平。然而，影响母乳脂肪浓度的因素值得进一步研究。
Breast milk samples from 38 women in New Zealand were analyzed for organochlorine pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) as part of a World Health Organization collaborative study of breast-milk contaminants. The women were recruited from two urban areas (Auckland and Christchurch) and two rural areas (Northland and North Canterbury) in the North and South Islands of New Zealand. The best predictor of contaminant concentrations in breast milk Has found to be the age of the mother. Regional differences were found for hexachlorobenzene, dieldrin, and pp-DDE, reflecting historical use patterns. Urban-rural differences were found for several PCBs, PCDDs, and PCDFs when contaminant concentrations were calculated on a whole-milk basis. However, these differences could be attributed to variation in breast-milk fat concentrations between urban and rural mothers. Urban mothers had about 50% more breast-milk fat than rural mothers. Evidence suggests that breast-milk consumption by babies is regulated by caloric intake. Almost all of the caloric content of milk is in the fat fraction. This suggests that breast-milk contaminant levels calculated on a whole-milk basis do not necessarily reflect the relative levels of exposure of infants to these contaminants. However, the factors that influence breast-milk fat concentration deserve further study.