Survival after Locoregional Recurrence or Second Primary Breast Cancer: Impact of the Disease-Free Interval
Survival after Locoregional Recurrence or Second Primary Breast Cancer: Impact of the Disease-Free Interval
复制标题
DOI：
10.1371/journal.pone.0120832
复制
发表时间：
2015-04-10
期刊：
影响因子：
3.7
通讯作者：
Siesling, Sabine
中科院分区：
文献类型：
--
作者：
Witteveen, Annemieke;Kwast, Annemiek B. G.;Siesling, Sabine
无病间隔 (DFI) 与局部区域复发 (LRR) 或第二原发性 (SP) 乳腺癌后的生存率之间的关联仍不确定。本研究的目的是澄清这种关联，以获得有关预期预后的更多信息。 2003 年至 2006 年间首次诊断出患有早期乳腺癌的女性选自荷兰癌症登记处。对首次诊断后五年内的 LRR 和 SP 肿瘤进行了检查。随后，这五年被分为三个相等的区间。使用 Kaplan-Meier 估计和多变量 Cox 回归分析确定 DFI 对 LRR 或 SP 肿瘤后生存的预后意义。随访截止至 2014 年 1 月 1 日。分析中共有 37,278 名女性。 LRR 或 SP 肿瘤分别被诊断为 890 例 (2.4%) 和 897 例 (2.4%)。较长的 DFI 与 LRR 后生存率的改善密切相关（长与短：HR 0.65，95% CI 0.48-0.88；中与短 HR 0.81，95% CI 0.65-1.01）。 LRR 后与生存改善相关的其他因素包括年龄较小（
The association between the disease-free interval (DFI) and survival after a locoregional recurrence (LRR) or second primary (SP) breast cancer remains uncertain. The objective of this study is to clarify this association to obtain more information on expected prognosis. Women first diagnosed with early breast cancer between 2003-2006 were selected from the Netherlands Cancer Registry. LRRs and SP tumours within five years of first diagnosis were examined. The five-year period was subsequently divided into three equal intervals. Prognostic significance of the DFI on survival after a LRR or SP tumour was determined using Kaplan-Meier estimates and multivariable Cox regression analysis. Follow-up was complete until January 1, 2014. A total of 37,278 women was included in the analysis. LRRs or SP tumours were diagnosed in 890 (2,4%) and 897 (2,4%) respectively. Longer DFI was strongly and independently related to an improved survival after a LRR (long versus short: HR 0.65, 95% CI 0.48-0.88; medium versus short HR 0.81, 95% CI 0.65-1.01). Other factors related to improved survival after LRR were younger age (