Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China
Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China
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中国台州HIV阳性与HIV阴性男性肛门人乳头瘤病毒感染率及基因型
DOI：
10.1017/s0950268818003205
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
He, N.
中科院分区：
文献类型：
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作者：
Liu, X.;Lin, H.;He, N.
摘要本研究旨在调查中国不同性取向男性肛门人乳头瘤病毒（HPV）感染的流行情况及基因型分布。2016-2017年在浙江省台州市进行了一项横断面研究。采用方便抽样的方法从艾滋病自愿咨询和检测诊所和疾病预防控制中心招募男性参与者。进行面对面的问卷调查，并收集肛管拭子进行HPV基因分型。共有160名艾滋病毒阳性和113名艾滋病毒阴性男性参加了这项研究。在HIV阳性者中，异性恋男性、同性恋男性和双性恋男性的HPV感染率分别为30.6%、74.1%和63.6%，而在HIV阴性者中，各型HPV感染率分别为8.3%、29.2%和23.8%。在HIV阳性男性中，最常见的基因型为HPV-58（16.9%）、HPV-6（15.6%）和HPV-11（15.0%），在HIV阴性男性中，最常见的基因型为HPV-16（4.4%）、HPV-52（4.4%）和HPV-6（3.5%）。曾经有过痔疮和曾经在排便后看到过组织上的血液与HPV感染有关。本研究人群中四分之一的HPV感染可被市售四价疫苗覆盖。男性尤其是HIV感染者肛门HPV感染率高，需要密切观察和进一步研究，以预防肛门癌。
Abstract This study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.