Effects of nifedipine and enalapril on glomerular structure and function in uninephrectomized SHR.
Effects of nifedipine and enalapril on glomerular structure and function in uninephrectomized SHR.
复制标题
硝苯地平和依那普利对未肾切除 SHR 肾小球结构和功能的影响。
DOI：
10.1038/ki.1991.141
复制
发表时间：
1991
影响因子：
19.6
通讯作者：
Tolbert,E
中科院分区：
文献类型：
--
作者：
Dworkin,LD;Feiner,HD;Parker,M;Tolbert,E
硝苯地平和依那普利对未肾切除SHR患者肾小球结构和功能的影响。自发性高血压大鼠（SHR）在6周龄时接受了肾切除术（UNX），随机分配到不接受治疗，钙通道阻滞剂硝苯地平或血管紧张素转换酶抑制剂依那普利。两种药物都能降低全身血压，然而，服用硝苯地平的大鼠血压往往比服用依那普利的大鼠高。6个月后，与未治疗的SHR组相比，治疗组的蛋白尿和肾小球硬化的患病率显著降低。治疗也减轻了肾脏重量，表明依那普利和硝苯地平均抑制代偿性肾脏生长。在同样处理的大鼠组中进行的微穿刺研究显示，未经处理的UNX SHR中pgc升高，硝苯地平和依那普利均降低。这些发现支持了肾小球高血压和肾肥大是肾小球损伤重要危险因素的假设。他们认为钙阻滞剂与血管紧张素转换酶抑制剂在预防进行性肾损害方面同样有效。
Effects of nifedipine and enalapril on glomerular structure and function in uninephrectomized SHR. Spontaneously hypertensive rats (SHR) that underwent uninephrectomy (UNX) at six weeks of age were randomly assigned to receive no treatment, the calcium channel blocker, nifedipine, or the angiotensin converting enzyme inhibitor, enalapril. Both drugs reduced systemic blood pressure, however, blood pressure tended to be greater in rats given nifedipine than in those on enalapril. After six months, proteinuria and the prevalence of glomerular sclerosis were significantly reduced in the two treated groups compared to values observed in untreated SHR. Kidney weight was also reduced by therapy, suggesting that both enalapril and nifedipine inhibited compensatory kidney growth. Micropuncture studies performed in similarly treated groups of rats, but at 11 weeks of age, revealed that PGCwas elevated in untreated UNX SHR and reduced by both nifedipine and enalapril. These findings support the hypothesis that glomerular hypertension and renal hypertrophy are important risk factors for glomerular injury. They suggest that calcium blockers are as efifective as angiotensin converting enzyme inhibitors in preventing progressive kidney damage.