Fever and the thermal regulation of immunity: the immune system feels the heat.
Fever and the thermal regulation of immunity: the immune system feels the heat.
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DOI：
10.1038/nri3843
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
Fisher DT
中科院分区：
文献类型：
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作者：
Evans SS;Repasky EA;Fisher DT
发烧是对感染的主要反应，在温血和冷血脊椎动物中已经保存了6亿多年的进化。发热反应是由综合的生理和神经回路执行的，并在感染期间赋予生存优势。在这里，我们回顾了我们目前对发烧热元素传递的炎症信号如何刺激先天和适应性免疫反应的理解。我们进一步强调了热原性细胞因子白介素-6 （IL-6）在发热诱导和淋巴细胞动员到淋巴器官（免疫防御的集结地）过程中意想不到的多重作用。最后，我们讨论了新出现的证据，表明肾上腺素能信号通路与产热影响免疫细胞功能有关。
Fever is a cardinal response to infection that has been conserved in warm and cold-blooded vertebrates for over 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. Here, we review our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction as well as during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. Finally, we discuss the emerging evidence that suggests the adrenergic signalling pathways associated with thermogenesis shape immune cell function.