The Relationship of Airway Hyperresponsiveness and Airway Airway Hyperresponsiveness in Asthma: Its Measurement and Clinical SignificanceInflammation
The Relationship of Airway Hyperresponsiveness and Airway Airway Hyperresponsiveness in Asthma: Its Measurement and Clinical SignificanceInflammation
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DOI：
10.1378/chest.10-0100
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发表时间：
2010-08-01
期刊：
影响因子：
9.6
通讯作者：
Busse, William W.
中科院分区：
文献类型：
--
作者：
Busse, William W.
气道高反应性（AHR）是哮喘的临床特征，通常与疾病的严重程度成比例。为了了解AHR和这些过程的机制，将影响哮喘这一特征的气道成分分为“持续性”和“可变性”类别是有帮助的。AHR的持续性成分代表气道的结构变化，而可变特征与炎症事件有关。通过研究哮喘激发的治疗效果和模型，可以深入了解AHR的这些相互关联的成分如何导致哮喘。胸部2010; 138（2）（增刊）：4S-10 S
Airway hyperresponsiveness (AHR) is a clinical feature of asthma and is often in proportion to the underlying severity of the disease. To understand AHR and the mechanisms that contribute to these processes, it is helpful to divide the airway components that affect this feature of asthma into "persistent" and "variable" categories. The persistent component of AHR represents structural changes in the airway, whereas the variable feature relates to inflammatory events. Insight into how these interrelated components of AHR can contribute to asthma is gained by studying treatment effects and models of asthma provocation. CHEST 2010; 138(2)(Suppl):4S-10S