Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes
Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes
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DOI：
10.1039/c2jm34999j
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发表时间：
2012-10-28
影响因子：
--
通讯作者：
Boyer, Cyrille
中科院分区：
文献类型：
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作者：
Beija, Mariana;Li, Yang;Boyer, Cyrille
我们提出了一种新的合成策略，以生产Gd（III）修饰的金纳米粒子（AuNPs）的双峰造影剂（CA）的计算机X射线断层扫描（CT）和磁共振成像（MRI）的潜在用途。混合金纳米颗粒表现出高的摩尔弛豫率（>12 000 mM（-1）s（-1）/颗粒），表明高效的CT/MRI CA。
We present a new synthetic strategy to produce Gd(III)-decorated gold nanoparticles (AuNPs) for potential use as bimodal contrast agents (CA) for computed X-ray tomography (CT) and magnetic resonance imaging (MRI). The hybrid AuNPs exhibit high molar relaxivities (>12 000 mM(-1) s(-1) per particle), indicative of highly efficient CT/MRI CAs.