Exaggerated neutrophil extracellular trap formation in Kawasaki disease: A key phenomenon behind the outbreak in western countries?
Exaggerated neutrophil extracellular trap formation in Kawasaki disease: A key phenomenon behind the outbreak in western countries?
复制标题
川崎病中性粒细胞胞外陷阱的过度形成：西方国家疫情爆发背后的一个关键现象？
DOI：
10.1136/annrheumdis-2020-218593
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发表时间：
2020
期刊：
影响因子：
27.4
通讯作者：
Mizugishi K.
中科院分区：
文献类型：
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作者：
Yamashita K;Takaori-Kondo A;Mizugishi K.
我们怀着极大的兴趣阅读了Pouletty等人最近发表在贵刊上的文章。1作者描述了巴黎地区16例与SARS-CoV-2（PIMS-TS）暂时相关的儿科炎症性多系统综合征病例。虽然受影响的儿童以完整或不完整的形式表现出川崎病（KD）的临床特征，但他们也表现出一些不同于KD的特征，例如发病年龄较大、心肌炎和/或心包炎的发生率较高，以及对静脉注射免疫球蛋白（IVIG）首次治疗的抵抗力。自2020年4月以来，美国和其他欧洲国家发现了类似病例。然而，PIMS-TS和KD是否具有共同的病因学和/或病理生理学，或者代表两种不同的临床实体，仍然是一个争论的问题。在此，我们探讨其爆发背后的原因与中性粒细胞胞外陷阱（NETs），一种新的中性粒细胞杀伤机制。KD是一种多系统血管炎，主要影响幼儿的冠状动脉，特别是在日本。虽然
We read with great interest the article by Pouletty et al recently published in your journal. 1 The authors described a series of 16 cases with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Paris area. While the affected children exhibited, in a complete or incomplete form, clinical features of Kawasaki disease (KD), they also presented several features distinct from KD, such as an older age at onset and a higher frequency of myocarditis and/or pericarditis, and of resistance to first treatment with intravenous immunoglobulin (IVIG). Clusters of similar cases have been identified in the USA and other European countries since April 2020. 2 3 However, it is still a matter of debate whether PIMS-TS and KD share aetiology and/or pathophysiology, or represent two distinct clinical entities. Herein, we explore the cause behind its outbreak in relation to neutrophil extracellular traps (NETs), a novel killing mechanism of neutrophils. KD is a multisystem vasculitis that primarily affects coronary arteries of young children, especially in Japan. Although