Drug-, dose- and sex-dependent effects of chronic fluoxetine, reboxetine and venlafaxine on open-field behavior and spatial memory in rats
Drug-, dose- and sex-dependent effects of chronic fluoxetine, reboxetine and venlafaxine on open-field behavior and spatial memory in rats
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DOI：
10.1016/j.bbr.2014.12.023
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发表时间：
2015-03-15
影响因子：
2.7
通讯作者：
Hughes, Robert N.
中科院分区：
文献类型：
--
作者：
Gray, Vanessa C.;Hughes, Robert N.
为了解决在SSRI氟西汀、NRI瑞博西汀和SNRI文拉法辛对焦虑相关行为和记忆的影响研究中纳入两种性别的需要，沿着使用慢性药物给药，对雄性和雌性PVG/c大鼠喂食含有两种剂量的每种药物的饲料，持续21天。然后在开阔的场地评估大鼠的焦虑水平。还测量了Y迷宫中亮度变化的短期空间记忆。虽然几乎没有证据表明任何药物具有抗焦虑作用，但氟西汀和文拉法辛（程度较轻）的作用似乎主要是致焦虑的，这取决于剂量和性别。在这方面，Reboxandum相对无效。氟西汀和文拉法辛似乎都损害了雄性（但不是雌性）大鼠定位已改变（从白色变为黑色）的Y-迷宫臂的能力，瑞波西汀的损害程度要小得多。考虑到reboxaline在任何一种测试中的相对无效性，其他两种药物对焦虑和记忆的影响可能主要是由于它们的血清素再摄取抑制特性。男性和女性之间对所有三种药物的反应性差异支持了长期以来的观点，即在这类研究中应调查两性，特别是考虑到临床处方抗抑郁药作用的性别差异报告。(C)© 2014 Elsevier B. V.保留所有权利。
In an effort to address the need to include both sexes in studies of effects of the SSRI fluoxetine, the NRI reboxetine and the SNRI venlafaxine on anxiety-related behavior and memory along with the use of chronic drug administration, male and female PVG/c rats were fed diets containing two doses of each drug for 21 days. The rats' anxiety level was then assessed in an open field. Short-term spatial memory for a brightness change in a Y maze was also measured. While there was little evidence of anxiolytic effects of any of the drugs, both fluoxetine and, to a lesser extent, venlafaxine appeared to be mainly anxiogenic in their action depending on both dose and sex. Reboxetine was relatively ineffective in this respect. Ability to locate the Y-maze arm that had changed (from white to black) seemed to be impaired for male (but not female) rats by both fluoxetine and venlafaxine and, to a much lesser extent, by reboxetine. Given the relative ineffectiveness of reboxetine in either test, it is possible that the effects of the other two drugs on both anxiety and memory were mainly due to their serotonin reuptake inhibiting properties. The differences that occurred between males and females in responsiveness to all three drugs supported the long-held view that both sexes should be investigated in studies of this sort, especially in view of reports of sex differences in effects of clinically prescribed antidepressants. (C) 2014 Elsevier B.V. All rights reserved.