Hepatitis C virus reinfection in injection drug users
Hepatitis C virus reinfection in injection drug users
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DOI：
10.1002/hep.21376
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发表时间：
2006-11-01
期刊：
影响因子：
13.5
通讯作者：
Tyndall, Mark W.
中科院分区：
文献类型：
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作者：
Grebely, Jason;Conway, Brian;Tyndall, Mark W.
丙型肝炎（HCV）的自发清除可能提供防止再感染的保护。在一项以社区为基础的大型队列研究中，研究人员对3553名市中心居民（主要是注射吸毒者）进行了研究，确定了hcv感染者，他们的病毒学清除已经发生，并将该组的再感染率与同一队列中先前未感染的成员的再感染率进行了比较。我们在基线时鉴定了926名hcv未感染和658名hcv感染的病毒血症患者，在中位随访5.2年（IQR, 2.8-7.4）期间，658名患者中有152名（23.1%）自行清除病毒血症。在基线时，清除HCV的个体更有可能合并感染HIV
Spontaneous clearance of hepatitis C (HCV) may provide protection against reinfection. In a large community-based cohort study of 3,553 inner-city residents (mainly injection drug users), we identified HCV-infected individuals in whom virological clearance had occurred and compared the rate of reinfection in this group with that observed in previously uninfected members of the same cohort. We identified 926 HCV-uninfected and 658 HCV-infected viremic subjects at baseline, with 152 of 658 (23.1%) spontaneously clearing viremia over a median follow-up of 5.2 years (IQR, 2.8-7.4). At baseline, individuals with HCV clearance were more likely to be HIV coinfected (P