Evidence for developmental changes in the visual word processing network beyond adolescence
Evidence for developmental changes in the visual word processing network beyond adolescence
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DOI：
10.1016/j.neuroimage.2005.09.023
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发表时间：
2006-02-01
期刊：
影响因子：
5.7
通讯作者：
Brandeis, D
中科院分区：
文献类型：
--
作者：
Brem, S;Bucher, K;Brandeis, D
采用事件相关电位（ERP）和功能磁共振成像（fMRI）技术，对青少年（15.2-17.3岁）和成年人（19.8-30.8岁）的文字和符号串加工进行了研究。我们将ERP分析的重点放在快速视觉活动上：枕叶P1（82-131 ms）受物理刺激特征的调制，枕叶-颞叶N1（132-256 ms）反映了印刷品的视觉调谐。我们的fMRI分析集中在视觉词形区VWFA的基础枕颞激活。换句话说，VWFA的fMRI激活与N1振幅的相关性证实了VWFA的电生理N1与代谢活动的密切关系。进一步支持这种关系来自低分辨率电磁断层扫描定位的字特定的N1附近的VWFA。这两种成像技术揭示了年龄无关的单词和符号串之间的差异。晚期发展，然而，优先检测与ERP。P1和N1振幅随年龄的下降并不局限于单词，这表明潜在的大脑微观结构和功能进一步成熟。在青春期之后，减少特定于单词的N1潜伏期表明视觉文字处理系统的持续专业化。N1和fMRI测量与阅读表现相关。总而言之，两组之间整体功能磁共振成像激活模式的相似性表明，阅读网络在青春期的分布是完全建立起来的，而单词的N1潜伏期的减少表明青春期后的长期微调。(c)2005年爱思唯尔公司All rights reserved.
Late development of specialization in the visual word processing system was examined using event-related potentials (ERP) and functional magnetic resonance imaging (fMRI) of word and symbol string processing in groups of adolescents (15.2-17.3 years) and adults (19.8-30.8 years). We focused our ERP analyses on fast visual activity: the occipital P1 (82-131 ms) modulated by physical stimulus characteristics and the occipito-temporal N1 (132-256 ms) reflecting visual tuning for print. Our fMRI analyses concentrated on basal occipito-temporal activations in the visual word form area VWFA. For words, the correlation of fMRI activation in the VWFA and N1 amplitude confirmed the close relationship of the electrophysioiogical N1 with metabolic activity in the VWFA. Further support for this relationship came from low resolution electromagnetic tomography localizing the word-specific N1 near the VWFA.Both imaging techniques revealed age-independent differences between words and symbol strings. Late development, however, was preferentially detected with ERPs. Decreases of P1 and N1 amplitudes with age were not limited to words and suggested further maturation of the underlying brain microstructure and function. Following adolescence, decreasing N1 latencies specific to words point to continued specialization of the visual word processing system. Both N1 and fMRI measures correlated with reading performance. In summary' the similarity of global fMRI activation patterns between groups suggests a fully established distribution of the reading network in adolescence, while the decreasing N1 latencies for words indicate protracted fine tuning after adolescence. (c) 2005 Elsevier Inc. All rights reserved.