Menopausal complaints are associated with cardiovascular risk factors
Menopausal complaints are associated with cardiovascular risk factors
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DOI：
10.1161/hypertensionaha.107.106526
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发表时间：
2008-06-01
期刊：
影响因子：
8.3
通讯作者：
van der Schouw, Yvonne T.
中科院分区：
文献类型：
--
作者：
Gast, Gerrie-Cor M.;Grobbee, Diederick E.;van der Schouw, Yvonne T.
据推测，有血管运动症状的女性与没有血管运动症状的女性在心血管危险因素或对外源性激素治疗的反应方面存在差异。我们研究了更年期主诉的存在和程度是否与心血管风险状况相关。数据来自1994年至1995年间登记的5523名年龄在46岁至57岁之间的以人口为基础的样本。通过问卷调查收集了有关更年期抱怨和潜在混杂因素的数据。测量总胆固醇、收缩压和舒张压，以及体重指数。数据分析采用线性和Logistic回归分析。据报道，38%的女性盗汗，39%的女性出现潮红。经多因素校正后，有潮红症状的女性与无症状女性相比，胆固醇水平高0.27-mmo1/L(95%CI：0.15-0.39)，体重指数高0.60-kg/m(2)(95%CI：0.35-0.84)，收缩压高1.59-mm Hg(95%CI：0.52-2.67)，舒张压高1.09-mm Hg(95%CI：0.48-1.69)。脸红还与高胆固醇血症(优势比：1.52；95%可信区间：1.25至1.84)和高血压(优势比：1.20；95%可信区间：1.07至1.34)相关。关于盗汗的投诉也有类似的结果。这一发现支持了这样的观点，即更年期主诉与不太有利的心血管风险状况有关。这些发现证实了这样一种观点，即更年期症状的存在作为使用激素治疗的原因的差异可以解释观察性研究和试验之间的差异。
It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate adjustment, women with complaints of flushing had a 0.27-mmol/L (95% CI: 0.15 to 0.39) higher cholesterol level, a 0.60-kg/m(2) (95% CI: 0.35 to 0.84) higher BMI, a 1.59-mm Hg (95% CI: 0.52 to 2.67) higher systolic blood pressure, and a 1.09-mm Hg (95% CI: 0.48 to 1.69) higher diastolic blood pressure compared with asymptomatic women. Flushing was also associated with hypercholesterolemia (odds ratio: 1.52; 95% CI: 1.25 to 1.84) and hypertension (OR: 1.20; 95% CI: 1.07 to 1.34). Results were similar for complaints of night sweating. The findings support the view that menopausal complaints are associated with a less favorable cardiovascular risk profile. These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials.