An updated structural classification of substrate-binding proteins
An updated structural classification of substrate-binding proteins
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DOI：
10.1002/1873-3468.12445
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发表时间：
2016-12-01
期刊：
影响因子：
3.5
通讯作者：
Poolman, Bert
中科院分区：
文献类型：
--
作者：
Scheepers, Giel H.;Lycklama a Nijeholt, Jelger A.;Poolman, Bert
底物结合蛋白（SBPs）在溶质摄取和信号转导中起着重要作用。2010年，Berntsson等人根据结构相似性对当时可用的114种生物特异性SBP结构进行了分类，并定义了6个蛋白质簇。从那时起，独特的SBP结构的数量增加了近五倍，而蛋白质数据库（PDB）中的蛋白质条目数量几乎翻了一番。在更大的数据集的基础上，我们现在对原始聚类中的SBP进行子分类。此外，我们提出了一个第7集群的基础上的一小群SBPs的结构特征显着不同的其他蛋白质。
Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins.