INFLUENCE OF PHOTOSENSITIZERS AND LIGHT ON THE LIFE-SPAN OF DROSOPHILA
INFLUENCE OF PHOTOSENSITIZERS AND LIGHT ON THE LIFE-SPAN OF DROSOPHILA
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DOI：
10.1016/0047-6374(93)90149-l
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发表时间：
1993-05-01
影响因子：
5.3
通讯作者：
WILLIAMS, TR
中科院分区：
文献类型：
--
作者：
MASSIE, HR;AIELLO, VR;WILLIAMS, TR
成年黑腹果蝇的寿命在喂食两种不同的光敏剂后发生了变化。当亚甲蓝在食物中的浓度为0.001 M时，中位寿命缩短了49%。另一种光敏剂，核黄素，在相同的条件下，12：12小时的光/暗周期，在白天的光强度为1000勒克斯的寿命没有变化。在2000勒克斯的光照强度下，暴露在持续黑暗中的果蝇比暴露在持续光照下的果蝇寿命长43.2%。在这些条件下，核黄素使暴露在恒定光照下的果蝇的寿命延长了25%。我们的结论是，核黄素赋予一定程度的保护，对不断曝光的影响。核黄素和亚甲蓝得到的完全不同的结果表明，光老化的可能机制涉及通过产生单线态氧介导的光动力作用。
The life span of adult Drosophila melanogaster fruit flies changed when they were fed two different photosensitizers. Methylene blue decreased the median life span by 49% when present in the food at a concentration of 0.001 M. Another photosensitizer, riboflavin, produced no changes in life span under the same conditions of a 12:12 h light/dark cycle at a daytime light intensity of 1000 lux. Flies exposed to constant darkness lived 43.2% longer than those exposed to constant light at a light intensity of 2000 lux. Under these conditions, riboflavin increased the life span of the flies exposed to constant light by as much as 25%. We conclude that riboflavin confers some degree of protection against the effects of constant light exposure. The completely different results obtained with riboflavin and methylene blue suggest a possible mechanism for photoageing involving photodynamic action mediated through the production of singlet oxygen.