Role of TRPV1 in inflammation-induced airway hypersensitivity.
Role of TRPV1 in inflammation-induced airway hypersensitivity.
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DOI：
10.1016/j.coph.2009.02.002
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发表时间：
2009-06
影响因子：
4
通讯作者：
Gu, Qihai
中科院分区：
文献类型：
--
作者：
Lee, Lu-Yuan;Gu, Qihai
气道过敏是各种气道炎症性疾病的共同病理生理特征。越来越多的证据表明，瞬时受体电位香草样蛋白1型受体（TRPV1）的激活在气道过敏各种症状的表现中起重要作用。这篇综述集中于最近的研究，这些研究揭示了气道炎症反应中肺感觉神经元TRPV1敏感性增加的几个潜在因素。此外，慢性过敏性气道炎症诱导结节神经节中神经丝阳性肺感觉神经元中TRPV1的明显过度表达。更好地了解急性和慢性气道炎症期间TRPV1敏感性和/或表达增加的机制，将为制定有效的治疗干预措施以减轻气道过敏提供必要的信息。
Airway hypersensitivity is a common pathophysiological feature in various airway inflammatory diseases. Increasing evidence suggests that activation of the transient receptor potential vanilloid type 1 receptor (TRPV1) plays an important part in the manifestation of various symptoms of airway hypersensitivity. This mini-review focuses on recent studies that have revealed several potential contributing factors to the increase in TRPV1 sensitivity in pulmonary sensory neurons during airway inflammatory reaction. In addition, chronic allergic airway inflammation induces a pronounced over-expression of TRPV1 in neurofilament-positive pulmonary sensory neurons in nodose ganglia. A better understanding of the mechanisms underlying the increase in sensitivity and/or expression of TRPV1 during acute and chronic airway inflammation should generate the necessary information for developing effective therapeutic interventions to alleviate airway hypersensitivity.
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