3 BULBOSPINAL PATHWAYS FROM ROSTRAL MEDULLA OF CAT - AUTORADIOGRAPHIC STUDY OF PAIN MODULATING SYSTEMS
3 BULBOSPINAL PATHWAYS FROM ROSTRAL MEDULLA OF CAT - AUTORADIOGRAPHIC STUDY OF PAIN MODULATING SYSTEMS
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DOI：
10.1002/cne.901780203
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
FIELDS, HL
中科院分区：
文献类型：
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作者：
BASBAUM, AI;CLANTON, CH;FIELDS, HL
少量的3h -亮氨酸被注射到猫的吻侧髓质的离散区域。用放射自显影方法研究这些部位的下降投影。根据对髓质和脊髓的不同投影，划定了3个不同的区域。巨细胞网状核（Rgc）位于髓网状结构的背侧，主要指向运动相关部位，包括颅运动核VI、VII、XII、胼胝体间核和同侧内侧副橄榄的一部分。脊髓的投射主要通过同侧腹外侧和对侧腹侧耻骨。Rgc终末区位于注射部位的同侧和对侧的VII和VIII椎板。相反，中缝大核（NRM）位于腹侧，位于延髓吻侧中线，主要指向已知有伤害感觉和/或内脏传入输入的结构。这些部位包括孤核、背运动核(X)和脊髓三叉尾核的边缘层和胶状层。脊髓的投影是双侧的，通过背外侧束。末梢场分布于背角的边缘区和胶质区，而在V、VI和VII内侧更深入。大细胞网状核（Rmc）位于NRM外侧和Rgc腹侧，与NRM有重叠投影，但投影是同侧的。Rmc和Rgc之间的这种差异与两个区域的细胞结构特征有关。讨论了DLF中膈-脊髓通路介导阿片类药物和脑刺激引起的镇痛的可能性。
Small amounts of 3H-leucine were injected into discrete regions in the rostral medulla of the cat. Descending projections from these sites were studied with autoradiographic methods. On the basis of differential projections to the medulla and spinal cord, 3 distinct regions were delineated. Nucleus reticularis gigantocellularis (Rgc) located dorsally in e medullary reticular formation, projects primarily to motor related sites, including cranial motor nuclei VI, VII, XII, nucleus intercalatus and a part of the ipsilateral medial accessory olive. The projection to the spinal cord is primarily via the ipsilateral ventrolateral and contralateral ventral funiculi. The Rgc terminal field is in lamina VII and VIII ipsilateral and lamina VIII contralateral to the injection site. In contrast, nucleus raphe magnus, (NRM) located ventrally, in the midline of the rostral medulla projects primarily to structures with known nociceptive and/or visceral afferent input. These sites include the solitary nucleus, the dorsal motor nucleus (X) and the marginal and gelatinous layers of the spinal trigeminal nucleus caudalis. The projection to the spinal cord is bilateral, via the dorsolateral funiculus. Terminal fields are found in the marginal zone and the substantia gelatinosa of the dorsal horn, and more deeply in lamina V, medial VI and VII. Nucleus reticularis magnocellularis (Rmc), located lateral to NRM and ventral to Rgc, has an overlapping projection with NRM, but the projection is ipsilateral. This difference between Rmc and Rgc is correlated with cytoarchitectural features of the 2 regions. The possibility that the raphe-spinal pathway in the DLF mediates opiate and brain stimulation-produced analgesia was discussed.