Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients
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DOI：
10.1007/s00406-008-0825-8
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Bogerts, Bernhard
中科院分区：
文献类型：
--
作者：
Gos, Tomasz;Krell, Dieter;Bogerts, Bernhard
我们的死后研究旨在确定自杀对自杀抑郁症患者蓝斑（LC）去肾上腺素能神经元数量的影响。免疫染色酪氨酸羟化酶显示22例非老年情绪障碍患者LC中有去甲肾上腺素能神经元，与21例年龄和性别匹配的正常对照相比。11名患者是自杀，另外11名患者是自然死亡。与非暴力自杀受害者和对照组相比，7名暴力自杀受害者的酪氨酸羟化酶免疫反应（TH-ir）神经元数量增加。有自杀倾向的患者与对照组之间、非有自杀倾向的患者与对照组之间的TH-ir神经元数量没有差异。th免疫反应性的差异既不能归因于药物治疗，也不能归因于抑郁症的极性（单极/双相）。自杀患者的TH-ir神经元数量与抗抑郁药的平均剂量呈负相关。本研究提示LC突触前去肾上腺素能失调与自我攻击水平有关。因此，传统的抗抑郁药可能调节自杀患者LC的去甲肾上腺素能活性，但没有显示出预防自杀的效果。
Our postmortem study aimed to determine the impact of suicide on the number of noradrenergic neurons of the locus coeruleus (LC) in suicidal depressive patients. Noradrenergic neurons were shown by immunostaining tyrosine hydroxylase in the LC of 22 non-elderly patients with mood disorders compared to 21 age- and sex-matched normal controls. Eleven patients were suicide victims and the other eleven died of natural causes. Seven violent suicide victims revealed an increased number of tyrosine hydroxylase immunoreactive (TH-ir) neurons compared with non-violent suicide victims and controls. No difference was found between the number of TH-ir neurons in all suicidal patients and controls and between non-suicidal patients and controls. The differences of TH-immunoreactivity could neither be attributed to medication nor to the polarity of depressive disorder (unipolar/bipolar). The numbers of TH-ir neurons in suicidal patients correlated negatively with the mean doses of antidepressants. The study suggested a presynaptic noradrenergic dysregulation in the LC related to the level of self-aggression. Traditional antidepressants may, therefore, regulate noradrenergic activity of the LC in suicide patients, however, without demonstrating the suicide-preventing effect.