Circadian rhythmicity and the community of clockworkers
Circadian rhythmicity and the community of clockworkers
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DOI：
10.1111/ejn.14626
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发表时间：
2019-12
影响因子：
3.4
通讯作者：
K. Gamble;R. Silver
中科院分区：
文献类型：
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作者：
K. Gamble;R. Silver
2017年诺贝尔生理学或医学奖因对果蝇昼夜节律的分子/细胞基础的研究而获得。这项在果蝇身上进行的研究是一个在随后的几十年中不断重复的原理的一个例子，即简单的模型系统可以揭示普遍的细胞和亚细胞事件。我们简要回顾了这项工作如何通过使研究生物钟如何在从分子到细胞、到组织/腺体到整个生物体的多个分析层面上工作成为可能，从而开辟了新的研究领域。诺贝尔奖提供了反思的动力：一个思考为什么 1980 年代初期所做的研究在多年后仍引起诺贝尔委员会关注的机会。细胞/分子时钟的发现之前和之后发生了什么？
The Nobel Prize in Physiology or Medicine in 2017 was awarded for the study of the molecular/cellular basis of circadian rhythms in flies. The work was on flies is an example of a principle, repeated in subsequent decades, that simple model systems can uncover universal cellular and subcellular events. We briefly trace how this work opened new fields of research by making it possible to examine how circadian clocks work across many levels of analysis, from molecules, to cells, to tissues/glands and to whole organisms. The Nobel award provided an impetus for reflection: an opportunity to contemplate why research done in the early 1980's drew the Nobel committee's attention so many years later. What anteceded and followed the discovery of the cellular/molecular clock?