Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo
Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo
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DOI：
10.1007/s10334-005-0007-x
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发表时间：
2005-11-01
影响因子：
2.3
通讯作者：
Ross, BD
中科院分区：
文献类型：
--
作者：
Bhattacharya, P;Harris, K;Ross, BD
目的：PASADENA是一种增强核自旋极化的化学方法，它证明了仲氢加成新生产物的C-13级极化。通过herpolarization获得的信号增强的极端短暂性需要改进的C-13 MR体内成像技术以获得最佳效用。材料和方法：在GE LX 1.5T临床MR扫描仪上，使用C-13序列，包括C-13 3D FIESTA。两种水溶性C-13成像剂利用仲氢和自动偏振器超偏振。C-13极化在流动幻影和大鼠颈静脉导管进行定量。结果：快速三维FIESTA C-13磁共振成像技术可获得序列三维图像（3.66 s/次），具有良好的上级信噪比。超极化C-13溶液和血管体模获得的最大信号为26，624 +/- 593。心肺循环的体内C-13 MR图像显示最大C-13信号为2，402 +/- 158。在3.66 s内采集的C-13图像显示，与平衡极化相比，信号增强超过10，000。结论：3D-FIESTA可有效用于定制仲氢偏振器中产生的超极化C-13试剂的亚秒级体内成像。在体外和体内证明了对仲氢超极化的C-13的应用。
Objective: PASADENA, a chemical method of enhancing nuclear spin polarization has demonstrated C-13 polarizations of order unity for the nascent products of molecular addition by parahydrogen. The extreme brevity of signal enhancement obtained by herpolarization requires improved C-13 MR in vivo imaging techniques for their optimum utility. Materials and Methods: C-13 imaging sequences, including C-13 3D FIESTA, were compiled for a GE LX 1.5 T clinical MR scanner. Two water soluble C-13 imaging agents were hyperpolarized utilizing parahydrogen and an automated polarizer. C-13 polarization was quantified in flow phantoms and in rats with jugular vein catheters. Results: Fast 3D FIESTA C-13 MR imaging technique acquired sequential 3D images (3.66 s/acquisition) with superior SNR. Hyperpolarized C-13 solutions and vascular phantoms achieved a maximum signal of 26,624 +/- 593. In vivo C-13 MR images of the cardiopulmonary circulation showed maximum C-13 signal of 2,402 +/- 158. C-13 images acquired within 3.66 s showed signal enhancement over 10,000 compared to equilibrium polarization. Conclusion: 3D-FIESTA was effective for sub-second in vivo imaging of hyperpolarized C-13 reagents produced in a custom-built parahydrogen polarizer. Application to C-13 hyperpolarized by parahydrogen is demonstrated in vitro and in vivo.