Sex Differences in Risk Factors for Oral and Pharyngeal Cancer among Puerto Rican Adults.
Sex Differences in Risk Factors for Oral and Pharyngeal Cancer among Puerto Rican Adults.
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发表时间：
2020
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通讯作者：
Ortiz AP
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作者：
Castañeda-Avila M;Pérez CM;Vivaldi J;Díaz-Toro EC;Centeno H;Ortiz AP
口咽癌（OPC）是波多黎各常见的癌症类型，男性的风险高于女性。我们评估了与这些性别差异有关的OPC风险因素的差异。我们分析了来自圣胡安超重成人纵向研究（SOALS）的740名成人参与者（40-65岁）的数据。进行了一项全面的问卷调查，以收集有关社会人口学特征、吸烟、酗酒、口腔高危HPV感染、水果和蔬菜消费、性行为和口腔卫生习惯的信息。还进行了全口牙周检查。对16种已知和潜在的OPC风险因素进行了评价。使用对数二项回归计算了按性别划分的单个OPC风险因素的粗患病率和校正患病率（PR）估计值。与女性相比，男性的几个OPC风险因素的患病率显著增加，包括当前吸烟（PR：1.91，95%置信区间[CI]：1.35-2.70），酗酒（PR：1.92，95% CI：1.31-2.84）和严重牙周炎（PR：2.05，95% CI：1.47-2.85）。男性比女性更有可能有OPC的危险因素。癌症预防和控制工作应侧重于有助于减少这种差异的针对性别的干预措施。
Oral and pharyngeal cancer (OPC) is a frequent type of cancer in Puerto Rico, with the risk being higher in men relative to women. We assessed differences in OPC risk factors implicated in these sex disparities. We analyzed data of 740 adult participants (40-65 years) from the San Juan Overweight Adults Longitudinal Study (SOALS). A comprehensive questionnaire was administered to collect information on sociodemographic characteristics, cigarette smoking, binge drinking, oral high-risk HPV infection, fruit and vegetable consumption, sexual behavior, and oral hygiene practices. A full-mouth periodontal examination was also performed. Sixteen OPC known and potential risk factors were evaluated. Crude and adjusted prevalence ratio (PR) estimates for individual OPC risk factors, by sex, were calculated using log-binomial regression. Compared to women, men had significantly increased prevalence of several OPC risk factors including current smoking (PR: 1.91, 95% Confidence interval [CI]: 1.35-2.70), binge drinking (PR: 1.92, 95% CI: 1.31-2.84), and severe periodontitis (PR: 2.05, 95% CI: 1.47-2.85). Men were significantly more likely than women to have risk factors for OPC. Cancer prevention and control efforts should focus on sex-specific interventions that help reduce this disparity.