Effects of piperazine oestrone sulphate on plasma tryptophan, oestrogens, gonadotropins and psychological functioning in women following hysterectomy
Effects of piperazine oestrone sulphate on plasma tryptophan, oestrogens, gonadotropins and psychological functioning in women following hysterectomy
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哌嗪雌酮硫酸盐对子宫切除术后女性血浆色氨酸、雌激素、促性腺激素和心理功能的影响
DOI：
10.1185/03007997709109381
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发表时间：
1977
影响因子：
2.3
通讯作者：
R. Beard
中科院分区：
文献类型：
--
作者：
A. Coppen;M. Bishop;R. Beard
摘要：一项为期3年的计划研究报告了子宫切除术后妇女的心理、激素和血浆色氨酸变化，这些妇女接受了哌嗪酮硫酸酯（每日1.5 mg）或安慰剂治疗6个月或更长时间。在接受哌嗪硫酸雌酮治疗的患者中，抑郁症状显著减轻，血浆总色氨酸显著增加。与激素治疗组相比，安慰剂治疗组没有出现这种变化，但血浆黄体生成素显著增加。
SummaryInterim findings are reported from a planned 3-year study of the psychological, hormonal and plasma tryptophan changes occurring in women following hysterectomy and who have been treated with either piperazine oestrone sulphate (1.5 mg b.d.) or placebo for 6 months or longer. In patients treated with piperazine oestrone sulphate, there was a highly significant reduction in depressive symptoms, and a significant increase in total plasma tryptophan. In contrast to the hormone-treated patients, the placebo-treated group showed no such changes, but a significant increase in plasma luteinizing hormone.