Neuroimmunological function in parents of children suffering from cancer
Neuroimmunological function in parents of children suffering from cancer
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DOI：
10.1007/s00702-013-1098-6
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Valevski, Avi
中科院分区：
文献类型：
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作者：
Benaroya-Milshtein, Noa;Apter, Alan;Valevski, Avi
本研究的主要目的是评估癌症儿童父母的抑郁与免疫功能的关系。32位家长参与了这项研究。父母完成了以下评估：血液肿瘤病房的主要压力事件列表，贝克抑郁量表II（BDI-II），创伤后诊断量表（PDS）和生活质量（QOL）问卷。从父母身上抽取一份血液样本，用于皮质醇水平和淋巴细胞亚群的评估。父母被分为两组：那些患有抑郁症的定义为BDI-II截止评分为14（抑郁的父母（DP），n = 7），和非抑郁的父母（非DP，n = 25）。在癌症儿童的父母中，DP组的压力事件评分、功能障碍评分（来自PDS）和CD 8百分比在统计学上显著高于非DP组。DP组的QOL、CD 4百分率和CD 4/CD 8比值均显著低于对照组。BDI评分与事件和功能障碍评分呈显著正相关，与QOL评分和CD 4/CD 8比值呈显著负相关。癌症儿童的父母精神病发病率高。DP免疫功能改变的发现进一步证明了对压力和抑郁的生理反应可能会改变免疫功能。
The main aim of this study is to evaluate the relationship between depression and immunological function in parents of children with cancer. Thirty-two parents participated in the study. The parents completed the following assessments: a list of major stressful events in a Hemato-Oncology ward, beck depression inventory II (BDI-II), posttraumatic diagnostic scale (PDS) and quality of life (QOL) questionnaire. A single blood sample was drawn from parents for evaluation of cortisol levels and lymphocyte cell subgroups. The parents were divided into two groups: Those who suffered from depression as defined by BDI-II cutoff score of 14 (depressed parents (DP), n = 7), and non-depressed parents (non-DP, n = 25). In parents of children with cancer the DP group had statistically significantly higher stressful event scores, dysfunction scores (from the PDS) and CD8 percentage compared to the non-DP group. QOL, CD4 percentage and CD4/CD8 ratio were significantly lower in the DP group. The BDI scores significantly positively correlated with events and dysfunctional scores, and significantly negatively correlated with QOL scores and CD4/CD8 ratio. High psychiatric morbidity was found in parents of children with cancer. The findings of altered immunity in DP provide further evidence that the physiological response to stress and depression may alter immune functions.