Enhanced Responsiveness to Photodynamic Therapy‐Induced Apoptosis after Mitochondrial DNA Depletion
Enhanced Responsiveness to Photodynamic Therapy‐Induced Apoptosis after Mitochondrial DNA Depletion
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DOI：
10.1111/j.1751-1097.1999.tb08305.x
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发表时间：
1999-12
影响因子：
3.3
通讯作者：
D. Kessel;Hai Sun
中科院分区：
文献类型：
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作者：
D. Kessel;Hai Sun
一些证据表明，线粒体是一个特别敏感的目标光损伤。光动力疗法（PDT）和顺铂药物之间的交叉耐药性的报告，沿着的证据表明，线粒体DNA（mtDNA）的耗竭敏化细胞顺铂建议的小鼠白血病对照L1210细胞与细胞的光动力反应的线粒体DNA耗尽的研究。线粒体DNA的丢失导致对线粒体光损伤的敏感性增加，而溶酶体光损伤的细胞毒性作用不受影响。与对照细胞相比，缺失线粒体DNA的细胞对涉及线粒体靶点的PDT表现出增强的调光反应。
Several lines of evidence indicate that mitochondria are an especially sensitive target for photodamage. Reports of cross resistance between photodynamic therapy (PDT) and the drug cisplatin, along with evidence that depletion of mitochondrial DNA (mtDNA) sensitized cells to cisplatin suggested a study of the photodynamic responsiveness of murine leukemia control L1210 cells versus cells depleted of mtDNA. Loss of mtDNA led to an increased sensitivity to mitochondrial photodamage, while the cytotoxic effects of lysosomal photodamage were not affected. Cells depleted of mtDNA showed an enhanced ap‐optotic response to PDT involving a mitochondrial target, compared with control cells.