Predominance of the contralateral movement-related activity in the subthalamo-cortical loop
Predominance of the contralateral movement-related activity in the subthalamo-cortical loop
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DOI：
10.1016/j.clinph.2006.06.719
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发表时间：
2006-10-01
影响因子：
4.7
通讯作者：
Defebvre, L.
中科院分区：
文献类型：
--
作者：
Devos, D.;Szurhaj, W.;Defebvre, L.
目的：异常的低频和高频振荡活动与帕金森病异常的运动控制有关。我们的目的是研究低频率和高频振荡活动是如何通过对侧和同侧皮质下环的运动调节的。方法：我们研究了丘脑下核（STN）区域和初级感觉运动（PSM）皮层电极接触记录的mu、β和γ节律事件相关的去同步（ERD）和同步（ERS）。结果：在PSM皮层和STN区比较，Mu和β ERD/ERS模式非常相似，而在对侧和同侧结构比较，Mu和β ERD/ERS模式非常不同。β节律性ERS在对侧结构中比在同侧结构中更占优势。伽马节律性ERS仅在对侧STN区域被记录（特别是在左旋多巴给药后）。对于所有患者，最佳双相衍生-由最早的mu和β ERD和最强的β和γ ERS定义的-总是包括产生最佳临床结果的STN电极接触。结论：运动相关活动参与了对侧丘脑皮层下回路的运动准备和双侧丘脑皮层下回路的运动执行。意义：对侧β节律性ERD似乎与肢体运动迟缓有关。(c) 2006年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Abnormal low- and high-frequency oscillatory activities have been linked to abnormal movement control in Parkinson's disease. We aimed to study how low- and high-frequency oscillatory activities are modulated by movement in the contralateral and ipsilateral subcorticocortical loops.Methods: We studied mu, beta and gamma rhythm event-related desynchronisation (ERD) and synchronisation (ERS) recorded from electrode contacts in the subthalamic nucleus (STN) areas and over the primary sensorimotor (PSM) cortex.Results: Mu and beta ERD/ERS patterns were very similar when comparing PSM cortex and STN areas and very different when comparing contralateral and ipsilateral structures. Beta rhythm ERS was more predominant over contralateral structures than over ipsilateral ones. Gamma rhythm ERS was only recorded from the contralateral STN area (particularly following administration of L-Dopa). For all patients, the best bipolar derivations - as defined by the earliest mu and beta ERD and the strongest beta and gamma ERS always included the STN electrode contacts that produced the best clinical results.Conclusions: Movement-related activity is involved in the movement preparation in the contralateral subthalamo-cortical loop and in the movement execution in the bilateral subthalamo-cortical loops.Significance: Contralateral beta rhythm ERD seemed to be related to bradykinesia of the limb performing the movement. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.