Mandibular and femoral growth alternation after sex hormone disruption in growing mice.
Mandibular and femoral growth alternation after sex hormone disruption in growing mice.
复制标题
生长中的小鼠性激素破坏后下颌骨和股骨的生长交替。
DOI：
10.1111/j.1601-6343.2011.01509.x
复制
发表时间：
2011
影响因子：
3.1
通讯作者：
Junji Ohtani
中科院分区：
文献类型：
--
作者：
Marquez Hernandez RA.;Junji Ohtani
引用这篇文章：Márquez Hernández RA, Ohtani J, Fujita T, Sunakawa H, Ishikawa E, Tsubamoto N, Kawata T, Kaku M, Motokawa M, Tanne K: 生长中小鼠性激素破坏后下颌和股骨的生长改变Orthod Craniofac Res2011;14:63–69Structured AbstractAuthors –Márquez Hernández RA、Ohtani J、Fujita T、Sunakawa H、Ishikawa E、Tsubamoto N、Kawata T、Kaku M、Motokawa M、Tanne K 目标 – 研究在生长小鼠中给予性激素特异性受体拮抗剂时如何影响下颌骨和股骨生长。材料和方法 – 本实验使用了 40 只 C57BL/6J 小鼠。 5日龄时，小鼠每天注射雌激素受体α（ERα）、β（ERβ）或雄激素受体（AR）拮抗剂，每4天评估一次体重。初次注射后一周、四周和八周，拍摄并测量下颌骨和股骨的射线照片。进行方差分析和成对比较（Fisher）以检查各组之间测量值的差异。结果 – 雄性小鼠在 4 周和 8 周时注射 ERβ 拮抗剂会影响下颌生长。在雌性小鼠中，当施用 ERβ 时，其生长在整个实验期间都受到影响。此外，在第8周时，注射ERα拮抗剂的雄性和雌性小鼠以及注射AR拮抗剂的雄性小鼠的下颌生长也受到影响。注射 ERβ 拮抗剂的雄性和雌性小鼠的股骨生长在整个实验期间均受到影响。此外，在第 8 周时，注射 ERα 拮抗剂的雄性和雌性小鼠以及注射 AR 拮抗剂的雄性小鼠的生长受到影响。 结论 – 小鼠下颌骨和股骨的生长部分是由于青春期前和青春期早期软骨细胞中 ERβ 的刺激而诱导的。在青春期后期和之后，雄性和雌性小鼠的生长是通过刺激 ERα 以及雄性小鼠的 AR 来诱导的。
To cite this article:Márquez Hernández RA, Ohtani J, Fujita T, Sunagawa H, Ishikawa E, Tsubamoto N, Kawata T, Kaku M, Motokawa M, Tanne K:
Mandibular and femoral growth alteration after sex hormone disruption in growing miceOrthod Craniofac Res2011;14:63–69Structured AbstractAuthors –Márquez Hernández RA, Ohtani J, Fujita T, Sunagawa H, Ishikawa E, Tsubamoto N, Kawata T, Kaku M, Motokawa M, Tanne KObjectives –To investigate how mandibular and femoral growth is affected when sex hormone– specific receptor antagonist is administered in growing mice.Materials and methods –Forty C57BL/6J mice were used in this experiment. At 5 days of age, the mice received daily injection of estrogen receptor alpha (ERα), beta (ERβ), or androgen receptor (AR) antagonists, and their body weight was assessed every 4 days. One, four and eight weeks after the initial injection, radiographs of the mandible and femur were taken and measured. Analyses of variance and pairwise comparisons (Fisher) were performed to examine the differences in values measured among the groups.Results –Mandibular growth was affected by ERβ antagonist injection in male mice at 4 and 8 weeks. In female mice, the growth was affected during all the experimental period, when ERβ was administered. Moreover, at 8 weeks, mandibular growth was also affected in male and female mice injected with ERα antagonist and in male mice injected with AR antagonist. Femoral growth was affected during all the experimental period in male and female mice injected with ERβ antagonist. Moreover, at 8 weeks, the growth was affected in male and female mice injected with ERα antagonist and in male mice injected with AR antagonist.Conclusions –Growth of the mandible and femur in mice, in part, is induced in response to the stimulation of ERβ in chondrocytes before and during early puberty. In late and after puberty, the growth is induced by the stimulation of ERα in male and female mice and that of AR in male mice.