An integrated pan-cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity.
An integrated pan-cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity.
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TFAP 4畸变的综合泛癌症分析和癌症免疫的潜在临床意义
DOI：
10.1111/jcmm.16147
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发表时间：
2021-03
影响因子：
5.3
通讯作者：
Chen QF
中科院分区：
文献类型：
--
作者：
Liu JN;Kong XS;Sun P;Wang R;Li W;Chen QF
研究表明，转录因子激活增强子结合蛋白4（TFAP 4）在多种类型的癌症中起着至关重要的作用;然而，TFAP 4的表达谱仍然未知，其在人类泛癌分析中的价值也是未知的。本研究综合分析了TFAP 4在33种恶性肿瘤中的表达模式，沿着TFAP 4在预后预测和肿瘤免疫中的意义。TFAP 4在不同的癌细胞系中表现出不一致的基因表达水平，并且在大多数恶性肿瘤中表现出异常表达，这与总生存率密切相关。更重要的是，TFAP 4水平也与肿瘤浸润程度显著相关。使用肿瘤浸润免疫细胞中的基因标记物和免疫评分将TFAP 4关联起来。TFAP 4表达与不同癌症类型中的肿瘤突变负荷和微卫星不稳定性相关，富集分析确定了TFAP 4相关术语和途径。本研究全面分析了TFAP 4在33种不同类型癌症中的表达，揭示了TFAP 4可能在癌症形成和发展过程中发挥重要作用。TFAP 4与癌症中不同程度的免疫浸润有关，这表明TFAP 4作为癌症免疫治疗靶点的潜力。我们的研究表明，TFAP 4作为一种预后生物标志物在肿瘤发生中起着重要作用，这突出了开发新的靶向治疗的可能性。
Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4) plays a vital role in multiple types of cancer; however, the TFAP4 expression profile is still unknown, as is its value within the human pan‐cancer analysis. The present study comprehensively analysed TFAP4 expression patterns from 33 types of malignancies, along with the significance of TFAP4 for prognosis prediction and cancer immunity. TFAP4 displayed inconsistent levels of gene expression across the diverse cancer cell lines, and displayed abnormal expression within most malignant tumours, which closely corresponded to overall survival. More importantly, the TFAP4 level was also significantly related to the degree of tumour infiltration. TFAP4 was correlated using gene markers in tumour‐infiltrating immune cells and immune scores. TFAP4 expression was correlated with tumour mutation burden and microsatellite instability in different cancer types, and enrichment analyses identified TFAP4‐associated terms and pathways. The present study comprehensively analysed the expression of TFAP4 across 33 distinct types of cancers, which revealed that TFAP4 may possibly play a vital role during cancer formation and development. TFAP4 is related to differing degrees of immune infiltration within cancers, which suggests the potential of TFAP4 as an immunotherapy target in cancers. Our study demonstrated that TFAP4 plays an important role in tumorigenesis as a prognostic biomarker, which highlights the possibility of developing new targeted treatments.
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影响因子：
14.9
作者：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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