A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids
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DOI：
10.1101/gr.116301.110
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发表时间：
2011-08-01
期刊：
影响因子：
7
通讯作者：
Wayne, Robert K.
中科院分区：
文献类型：
--
作者：
vonHoldt, Bridgett M.;Pollinger, John P.;Wayne, Robert K.
为模式物种开发的高通量基因分型技术可能会提高野生亲缘动物的人口统计学历史和祖先的分辨率。我们使用一个SNP基因分型微阵列开发的国内狗检测变异超过48K位点在世界范围内的狗样物种。尽管这些大型食肉动物的高流动性，我们发现不同的等级人口单位内灰狼和郊狼，人口之间的地理和生态差异相对应。此外，我们测试有争议的理论的祖先的五大湖狼和红狼使用的单倍型块在所有38犬科动物常染色体的分析。我们发现，这些神秘的犬科动物是高度混合的品种来自灰狼和郊狼，分别。这种不同的基因组历史表明，它们并不像以前的研究人员所提出的那样具有共同的近期祖先。种间杂交，以及进化分歧的过程中，可能是负责观察到的两种形式的表型区别。这种混合使有关濒危物种恢复和保护的决定复杂化。
High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarray developed for the domestic dog to assay variation in over 48K loci in wolf-like species worldwide. Despite the high mobility of these large carnivores, we find distinct hierarchical population units within gray wolves and coyotes that correspond with geographic and ecologic differences among populations. Further, we test controversial theories about the ancestry of the Great Lakes wolf and red wolf using an analysis of haplotype blocks across all 38 canid autosomes. We find that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively. This divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers. Interspecific hybridization, as well as the process of evolutionary divergence, may be responsible for the observed phenotypic distinction of both forms. Such admixture complicates decisions regarding endangered species restoration and protection.