MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer.
MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer.
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DOI：
10.2478/raon-2013-0062
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发表时间：
2013
影响因子：
2.4
通讯作者：
Glavac D
中科院分区：
文献类型：
--
作者：
Hauptman N;Glavac D
非编码RNA(NcRNAs)是细胞过程中的关键调节分子，是许多疾病的潜在生物标志物。目前，由于microRNAs和Long-Non-Coding RNAs的表达谱能够区分不同的癌症类型并对其亚型进行分类，因此它们正被用作癌症的诊断和预后生物标记物以及治疗工具。有许多研究证实，ncRNAs参与了癌症的发生、发展和发展，但直到最近才被确定为新的诊断和预后工具。这在未来的医学癌症治疗方案中可能是有益的，因为ncRNAs是天然的反义相互作用因子，包括在许多与生存和增殖相关的基因的调控中。研究的方向是开发癌症诊断和预后的有用标记物，以及开发基于RNA的新癌症疗法，其中一些已经在临床试验中。
Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potential biomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic and prognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish different cancer types and classify their sub-types. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development and progression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficial in future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulation of many genes connected to survival and proliferation. Research is directed in development of useful markers for diagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are already in clinical trials.
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