Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
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DOI：
10.4161/cc.10.24.18567
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发表时间：
2011-12-15
期刊：
影响因子：
4.3
通讯作者：
Venkatesh, Byrappa
中科院分区：
文献类型：
--
作者：
Lane, David P.;Madhumalar, Arumugam;Venkatesh, Byrappa
对软骨鱼（软骨鱼纲）成员象鲨（Callorhinchus milii）的基因组分析表明，它编码 p53 基因家族的所有三个成员：p53、p63 和 p73，每个成员都与骨脊椎动物（骨鱼纲）中的相应基因具有明显的同源性。因此，导致脊椎动物中出现三个家族成员的基因复制事件可以追溯到志留纪之前。它还编码 Mdm2 和 Mdm4 基因，但不编码 p19(Arf) 基因。对脊椎动物中这些蛋白质的氨基酸序列的详细比较表明，它们以高度独特的速率进化，并且这种变异不仅发生在三个家族成员之间，而且延伸到每个蛋白质的不同结构域。
Analysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the p19(Arf) gene. Detailed comparison of the amino acid sequences of these proteins in the vertebrates reveals that they are evolving at highly distinctive rates, and this variation occurs not only between the three family members but extends to distinct domains in each protein.