GABAergic feedforward projections from the inferior colliculus to the medial geniculate body.
GABAergic feedforward projections from the inferior colliculus to the medial geniculate body.
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DOI：
10.1073/pnas.93.15.8005
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发表时间：
1996-07
影响因子：
11.1
通讯作者：
J. Winer;Anddouglasl . Oliver
中科院分区：
文献类型：
--
作者：
J. Winer;Anddouglasl . Oliver
使用轴浆运输方法结合免疫细胞化学，在猫身上发现了从含γ-氨基丁酸（GABA能）下丘神经元到中膝状体（MGB）的新颖而强大的投射。该输入通过经典的下丘投射到 MGB，并且它是通向可能具有抑制性的感觉丘脑的直接上行 GABA 能通路。这种双侧投射构成了听觉顶丘脑系统中 10-30% 的神经元。其他人的研究表明，不存在对相应丘脑视觉或感觉核团的可比输入。这表明单突触抑制或去抑制是 MGB 的一个显着特征，神经回路的差异将其与丘脑视觉和感觉对应物区分开来。
A novel and robust projection from gamma-aminobutyric acid-containing (GABAergic) inferior colliculus neurons to the media] geniculate body (MGB) was discovered in the cat using axoplasmic transport methods combined with immunocytochemistry. This input travels with the classical inferior colliculus projection to the MGB, and it is a direct ascending GABAergic pathway to the sensory thalamus that may be inhibitory. This bilateral projection constitutes 10-30% of the neurons in the auditory tectothalamic system. Studies by others have shown that comparable input to the corresponding thalamic visual or somesthetic nuclei is absent. This suggests that monosynaptic inhibition or disinhibition is a prominent feature in the MGB and that differences in neural circuitry distinguish it from its thalamic visual and somesthetic counterparts.