Retinoylserine and retinoylalanine, natural products of the moth Trichoplusia ni.
Retinoylserine and retinoylalanine, natural products of the moth Trichoplusia ni.
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视黄酰丝氨酸和视黄酰丙氨酸是Trichoplusia ni蛾的天然产物。
DOI：
10.1021/np0496791
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发表时间：
2005
影响因子：
5.1
通讯作者：
Hammerling,Ulrich
中科院分区：
文献类型：
--
作者：
Rogge,Barbara;Itagaki,Yasuhiro;Fishkin,Nathan;Levi,Ester;Rühl,Ralph;Yi,San-San;Nakanishi,Koji;Hammerling,Ulrich
昆虫细胞将维生素A转化为许多维甲酸，这些维甲酸在进化上与哺乳动物细胞的维甲酸同源。然而，昆虫细胞也会产生额外的天然维甲酸。也就是说，从甘蓝环纹夜蛾的细胞系中分离到两个维甲酸多肽：N-反式维甲酸丝氨酸(1)和N-反式维甲酸丙氨酸(2)。这些是天然维甲酸通过酰胺键与氨基酸连接的第一个例子；氨基酸部分以更常见的构型描述，尽管由于样本量很少，无法确定绝对构型。
Insect cells convert vitamin A into a number of retinoids that are evolutionarily conserved with those of mammalian cells. However, insect cells also produce additional natural retinoids. Namely, two retinoic acid peptides,N-trans-retinoylserine (1) andN-trans-retinoylalanine (2), have been isolated from a cell line of the common cabbage looper,Trichoplusia ni. These are the first examples of naturally occurring retinoic acid linked to amino acids through an amide bond; the amino acid moieties are depicted in the more commonl-configuration, although the absolute configuration was not determined due to the minuscule sample amount.