A half century of fish gonadotropin‐releasing hormones: Breaking paradigms
A half century of fish gonadotropin‐releasing hormones: Breaking paradigms
复制标题
DOI：
10.1111/jne.13069
复制
发表时间：
2021-11
影响因子：
3.2
通讯作者：
Y. Zohar;N. Zmora;V. Trudeau;J. Muñoz-Cueto;Matan Golan
中科院分区：
文献类型：
--
作者：
Y. Zohar;N. Zmora;V. Trudeau;J. Muñoz-Cueto;Matan Golan
鱼类促性腺激素释放激素（GnRHs）领域也在今年庆祝其成立50周年。这篇综述提供了过去50年来鱼类GnRH生物学的时间顺序历史。它展示了在鱼类中关于GnRH和GnRH受体多样性的发现，GnRH神经元之间的动态相互作用，以及与GnRH一起作用的其他神经内分泌因子等，如何推动了我们对脊椎动物（包括哺乳动物）GnRH系统和功能的理解的范式转变。报告描述了技术创新在促进科学发现方面的作用，以及鱼类GnRH的基础研究如何导致水产养殖的转化成果。讨论了鱼类和哺乳动物GnRH研究之间的交流，以及使用鱼类模型推进GnRH生物学的价值和效用。提出了当前的挑战和未来的展望，希望扩大神经内分泌学科学界的对话和合作，利用多样化的模型动物和比较策略的使用。
The field of fish gonadotropin‐releasing hormones (GnRHs) is also celebrating its 50th anniversary this year. This review provides a chronological history of fish GnRH biology over the past five decades. It demonstrates how discoveries in fish regarding GnRH and GnRH receptor multiplicity, dynamic interactions between GnRH neurons, and additional neuroendocrine factors acting alongside GnRH, amongst others, have driven a paradigm shift in our understanding of GnRH systems and functions in vertebrates, including mammals. The role of technological innovations in enabling scientific discoveries is portrayed, as well as how fundamental research in fish GnRH led to translational outcomes in aquaculture. The interchange between fish and mammalian GnRH research is discussed, as is the value and utility of using fish models for advancing GnRH biology. Current challenges and future perspectives are presented, with the hope of expanding the dialogue and collaborations within the neuroendocrinology scientific community at large, capitalizing on diversifying model animals and the use of comparative strategies.