Right heart dysfunction in heart failure with preserved ejection fraction
Right heart dysfunction in heart failure with preserved ejection fraction
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DOI：
10.1093/eurheartj/ehu193
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发表时间：
2014-12-21
影响因子：
39.3
通讯作者：
Borlaug, Barry A.
中科院分区：
文献类型：
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作者：
Melenovsky, Vojtech;Hwang, Seok-Jae;Borlaug, Barry A.
目的心力衰竭并保留射血分数(HFpEF)患者右心功能不佳。方法和结果96例心衰并保留射血分数的患者和46例对照组接受了右心导管术、超声心动图评估和随访。HFpEF组右心充盈压、左心充盈压、肺动脉压和右室内径均高于对照组，而左室大小和EF无明显差异。33%的HFpEF患者存在右室功能不全(由右室面积变化分数定义，FAC和Lt；35%)，且与更严重的症状和更大的共病负担相关。与使用两种负荷依赖的对照组相比，HFpEF组右心功能受损(FAC：40+/-10vs.53+/-7%，P
Aim Right heart function is not well characterized in patients with heart failure and preserved ejection fraction (HFpEF). The goal of this study was to examine the haemodynamic, clinical, and prognostic correlates of right ventricular dysfunction (RVD) in HFpEF.Methods and results Heart failure and preserved ejection fraction patients (n = 96) and controls (n = 46) underwent right heart catheterization, echocardiographic assessment, and follow-up. Right and left heart filling pressures, pulmonary artery (PA) pressures, and right-sided chamber dimensions were higher in HFpEF compared with controls, while left ventricular size and EF were similar. Right ventricular dysfunction (defined by RV fractional area change, FAC< 35%) was present in 33% of HFpEF patients and was associated with more severe symptoms and greater comorbidity burden. Right ventricular function was impaired in HFpEF compared with controls using both load-dependent (FAC: 40+/-10 vs. 53+/-7%, P