Human papillomavirus prevalence and type distribution in male anogenital sites and semen
Human papillomavirus prevalence and type distribution in male anogenital sites and semen
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DOI：
10.1158/1055-9965.epi-06-0997
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发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Giuliano, Anna R.
中科院分区：
文献类型：
--
作者：
Nielson, Carrie M.;Flores, Roberto;Giuliano, Anna R.
背景：人乳头瘤病毒（HPV）是一种性传播病毒，可导致宫颈癌。虽然HPV可以感染男性和女性，但对男性的感染知之甚少。具体而言，类型特异性HPV感染的患病率和感染的分布在男性的肛门生殖器解剖部位是不完全表征。方法：我们对463名年龄在18 - 40岁的男性在龟头/冠、阴茎轴、阴囊、尿道、肛周区域、肛管和精液样本中检测HPV。符合条件的男性承认没有生殖器疣病史，并且在过去一年内与女性发生过性行为。对7个采样点的标本分别进行了37种类型的HPV PCR检测和反向线印迹基因分型检测。结果：当考虑来自任何采样地点的HPV结果时，237（51.2%）名男性至少有一种致癌或非致癌HPV型呈阳性，另外66（14.3%）名男性未分类HPV型呈阳性。HPV-16型（11.4%）和84型（10.6%）患病率最高。外生殖器样本（龟头/冠、轴和阴囊）比肛门样本更可能含有致癌HPV（25.1%对5.0%）。HPV阳性的阴茎轴和龟头/冠样本也比其他部位更容易感染多种HPV类型。结论：更完整的肛门生殖器采样和37种HPV类型的敏感检测导致HPV在主要无症状男性中的患病率高于先前报道。阴茎轴是最可能是HPV阳性的部位，并且多种类型和致癌感染的比例最大。这些结果对研究男性之间的HPV和伴侣之间的传播具有启示意义。
Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized.Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites.Results: When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4%) and 84 (10.6%). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1% versus 5.0%). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites.Conclusions: More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.