Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.
Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.
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DOI：
10.2741/e156
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发表时间：
2010-06
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影响因子：
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通讯作者：
Yasufumi Seki;A. Ichihara;Y. Mizuguchi;Mariyo Sakoda;Asako Kurauchi-Mito;T. Narita;Kenichiro Kinouchi;K. Bokuda;H. Itoh
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文献类型：
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作者：
Yasufumi Seki;A. Ichihara;Y. Mizuguchi;Mariyo Sakoda;Asako Kurauchi-Mito;T. Narita;Kenichiro Kinouchi;K. Bokuda;H. Itoh
为了检查肾素（原）受体在链脲佐菌素诱导的雄性糖尿病 SHRsp 加速器官损伤中的作用，将高盐饮食喂养的大鼠分为 5 组：用媒介物治疗的组、用 15 mg/kg/天的咪达普利（ACEi）治疗的组、用 60 mg/kg/天的咪达普利（高 ACEi）治疗的组、 用手柄区肽(HRP)处理的组，以及用ACEi和HRP两者处理的组(ACEi+HRP)。 8周后，载体组和HRP组的动脉压相似，而ACEi治疗组的动脉压下降。在接受 ACEi 和/或 HRP 治疗的组中，肾血管紧张素 II 含量也有类似的下降。 ACEi、高 ACEi 和 HRP 组的尿蛋白排泄量也减少，并且 ACEi+HRP 组的尿蛋白排泄量进一步显着减少。 ACEi+HRP 组的心脏重量显着低于任何其他组，尽管在接受 ACEi 和/或 HRP 治疗的组中心脏血管紧张素 II 水平也同样下降。因此，肾素（原）受体有助于加速糖尿病 SHRsp 心脏和肾脏的发病机制。
To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocin-induced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.