Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue
Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue
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由金属有机框架和离子液体衍生的分层多孔碳异质结片阵列用于癌症组织中 H2O2 电化学检测
DOI：
10.1007/s12274-020-3176-z
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发表时间：
2020-11
期刊：
影响因子：
9.9
通讯作者：
Lin Wang
中科院分区：
文献类型：
--
作者：
Yan Zhang;Qiying Lv;Kai Chi;Qilin Li;Huiling Fan;Bo Cai;Fei Xiao;Shuai Wang;Zheng Wang;Lin Wang
分级纳米结构的发展被证明是提高电催化剂催化活性和稳定性的有效策略。在此，使用金属有机骨架（MOF）FA和绿色离子液体作为前体，设计并在柔性碳纤维（CF）上生长了一种新型叶状分层多孔异质结片阵列（FA），集成石墨N掺杂碳（NC）与非晶B,N掺杂碳（BNC）。分级异质结结构具有微米级和纳米级的孔隙、大的表面积和暴露的高密度催化活性位点，增强了电子传导性，并提供了可访问的传输通道，有效降低了传质阻力。离散傅里叶变换（DFT）计算和实验的结果也表明异质结结构通过缩小带隙提高了催化活性。因此，所得纳米混合微电极对H2O2表现出优异的电化学传感性能，检测限低至50 nM，灵敏度高至213 μA×mM-1×cm-2，并且具有良好的抗干扰能力。通过实时监测活结肠细胞和手术切除的新鲜结肠癌组织释放的H2O2，探索了纳米混合纤维微电极的实际应用，这可以为识别不同类型的细胞以及区分癌细胞与正常细胞提供重要信息。我们相信这项研究将为开发先进碳纳米材料在电化学、生物传感和癌症诊断领域的应用铺平道路。
The development of hierarchical nanostructure is demonstrated as an effective strategy to improve catalytic activity and stability of electrocatalysts. Herein, a novel leaf-like hierarchically porous heterojunction flake arrays (FAs), integrated graphitic N-doped carbon (NC) with amorphous B,N-doped carbon (BNC), has been designed and grown on flexible carbon fiber (CF) using metal-organic framework (MOF) FAs and green ionic liquids as precursors. The hierarchical heterojunction structure possesses micro- and nano-scaled pores, large surface areas, and exposed high-density catalytic active sites, which enhances electronic conductivity and offers accessible transport channels for effectively decreasing mass transport resistance. The results of discrete Fourier transform (DFT) calculations and experiments also suggest that the catalytic activity has been promoted by the heterojunction structure through narrowing the banding gap. Consequently, the resultant nanohybrid microelectrode exhibits remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 50 nM, and a high sensitivity of 213 μA×mM-1×cm-2, as well as good anti-interference capability. The practical application of nanohybrid fiber microelectrode has been explored by real-time monitoring H2O2 released from live colon cells and surgically-resected fresh colon cancer tissue, which can provide important information for the identification of different types of cells as well as distinguish cancer cells from normal ones. We believe this research will pave the way towards the development of advanced carbon nanomaterials for application in the fields of electrochemistry, biosensing, and cancer diagnosis.
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影响因子：
29.4
作者：
Shenlong Zhao;Da‐Wei Wang;R. Amal;L. Dai
通讯作者：
Shenlong Zhao;Da‐Wei Wang;R. Amal;L. Dai
影响因子：
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作者：
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影响因子：
13.3
作者：
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通讯作者：
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影响因子：
9.9
作者：
Qu, Guoxing;Wu, Tianli;Yue, Qin
通讯作者：
Yue, Qin
影响因子：
10.9
作者：
Guan, Lu;Pan, Lei;Wu, Mingbo
通讯作者：
Wu, Mingbo