Synthesis, characterization and antibacterial activity of a biocompatible silver complex based on 2,2 '-bipyridine and 5-sulfoisophthalate
Synthesis, characterization and antibacterial activity of a biocompatible silver complex based on 2,2 '-bipyridine and 5-sulfoisophthalate
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DOI：
10.1016/j.ica.2016.07.014
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发表时间：
2016
影响因子：
2.8
通讯作者：
Wang Yan
中科院分区：
文献类型：
--
作者：
Jiang Yu;Zhu Cheng-Feng;Zheng Zhi;He Jian-Bo;Wang Yan
将2,2′-联吡啶（bipy）的抗菌性能与Ag离子的生物相容性和5-磺基间苯二甲酸盐（H2SIP−）的溶解度相结合，合成了一种新的抗菌配合物Ag(bpiy)2（H2SIP）·2H2O。通过粉末x射线衍射、红外光谱、紫外光谱和热分析对配合物进行了表征。单分子结构由一个金属配位阳离子（[Ag(bipy)2]+）、一个独立阴离子（H2SIP−）和两个溶剂水分子三部分组成。通过最小抑菌浓度（MIC）和抑菌区试验评价其抑菌效果。结果表明，银配合物对大肠杆菌具有较好的抑菌活性。杆菌,金黄色葡萄球菌(S。金黄色葡萄球菌)和枯草芽孢杆菌(B。微小)。
A new antibacterial complex, Ag(bpiy)2(H2SIP)·2H2O, was synthesized, based on an idea of combining the antibacterial properties of 2,2′-bipyridine (bipy) with the biocompatibility of Ag ions and the solubility of 5-sulfoisophthalate (H2SIP−). The complex was fully characterized by powder X-ray diffraction, IR spectra, ultraviolet spectra and thermal analyses. The single molecule structure consists of three parts, that is, a metal coordination cation ([Ag(bipy)2]+), an independent anion (H2SIP−) and two solvent water molecules. The antibacterial effects were evaluated by minimal inhibition concentration (MIC) and inhibition zone testing. The results indicate that the silver complex has the superior bacteriostatic activity againstEscherichia coli(E. coli),Staphylococcus aureus(S. aureus) andBacillus subtilis(B. subtilis).