Liposomal delivery of camptothecins.
Liposomal delivery of camptothecins.
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DOI：
10.1016/s1461-5347(00)00268-6
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发表时间：
2000-06-01
期刊：
影响因子：
--
通讯作者：
Emerson
中科院分区：
文献类型：
--
作者：
Emerson
以喜树碱为基础的药物为例，使用脂质体给药系统来提高药剂的治疗指数。这类高活性抗癌药物具有独特的作用机制，但也存在一些固有的缺陷，这些缺陷本可以通过脂质体配方来解决。最近的研究表明，这些脂质体配方药物具有保护作用、增加肿瘤递送和延长血浆暴露时间。药物开发方面的这些进展可能会提高这些药物的活性水平，并增加它们作为新的抗癌疗法的临床实用性。
The use of liposomal drug delivery systems to improve the therapeutic index of pharmaceutical agents is exemplified by camptothecin-based drugs. This highly active class of anticancer agents possesses a unique mechanism of action with some inherent shortcomings, which might have been solved by liposomal formulation. Recent studies have revealed the protective action, increased tumor delivery and prolonged plasma exposure of these liposomal formulated drugs. These advances in pharmaceutical development could increase the levels of activity of these agents, as well as increase their clinical utility as new emerging anticancer therapies.