Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis
Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis
复制标题
色素性网状脂溢性角化病引起的色素性鲍文病
DOI：
10.1007/s10147-010-0086-1
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发表时间：
2010
影响因子：
3.3
通讯作者：
T. Terada
中科院分区：
文献类型：
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作者：
T. Terada
一名76岁的男子咨询我们的医院抱怨一个黑色肿瘤的颞头。肿瘤为黑色结节状肿块，大小1 × 1 × 0.6cm。临床诊断为基底细胞癌，并进行了广泛的边缘切除。组织学上，肿瘤是对称的，在中心的角质化。中心存在被认为是恶性细胞的非典型细胞聚集体。没有入侵被确认。细胞色素沉着。有丝分裂的数字，个别角质化，并凝集细胞也被认可。恶性病变中可见大量树突状黑素细胞。免疫组化显示，所有恶性细胞均存在强p53表达，且恶性细胞显示60%的高Ki-67标记。黑素体和S100蛋白阴性，细胞角蛋白阳性。肿瘤周围表现为典型的色素性网状脂溢性角化病。两个病灶之间逐渐融合。本病例提示色素性网状脂溢性角化病可引起色素性鲍恩病。
A 76-year-old man consulted to our hospital complaining of a black tumor of the temporal head. The tumor was nodular mass measuring 1 × 1 × 0.6 cm and black. A clinical diagnosis of basal cell carcinoma was made, and an excision with wide margins was performed. Histologically, the tumor was symmetrical, with horny keratinization in the center. An aggregate of atypical cells regarded as malignant cells was present in the center. No invasion was recognized. The cells were heavily pigmented. Mitotic figures, individual keratinization, and clumping cells were also recognized. Numerous dendritic melanocytes were recognized in the malignant lesion. Immunohistochemically, strong p53 expression was present in all malignant cells, and the malignant cells showed a high Ki-67 labeling of 60%. They were negative for melanosome and S100 protein and positive for cytokeratins. The periphery of the tumor showed typical features of pigmented reticulated seborrheic keratosis. There were gradual merges between the two lesions. This case suggests that pigmented Bowen disease can arise in pigmented reticulated seborrheic keratosis.