Nilvadipine prevents cognitive decline of patients with mild cognitive impairment
Nilvadipine prevents cognitive decline of patients with mild cognitive impairment
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DOI：
10.1002/gps.1851
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发表时间：
2007-12-01
影响因子：
4
通讯作者：
Iwamoto, Toshihiko
中科院分区：
文献类型：
--
作者：
Hanyu, Haruo;Hirao, Kentaro;Iwamoto, Toshihiko
本文研究了尼伐地平治疗对轻度认知障碍（MCI）患者认知功能的长期影响，以确定尼伐地平是否可以延缓阿尔茨海默病（AD）的临床进展。本研究纳入了15例伴有原发性高血压的遗忘性轻度认知损伤患者。结果显示，尼伐地平组在20个月内保持稳定，而氨氯地平组有恶化趋势。研究表明，尼伐地平可以预防轻度认知损伤患者的认知能力下降。
The article presents a study which investigated the long-term effects of therapy with nilvadipine on the cognitive function in patients with mild cognitive impairment (MCI) to determine whether nilvadipine may delay clinical progression to Alzheimer's disease (AD). In this study, 15 amnestic MCI patients with essential hypertension were enrolled. Results showed that the nilvadipine group remained stable up to 20 months, whereas the amlodipine group tended to worsen. The study showed that nilvadipine may prevent cognitive decline of patients with MCI.