Promoter DNA methylation of CD10 in lymphoid malignancies.
Promoter DNA methylation of CD10 in lymphoid malignancies.
复制标题
淋巴恶性肿瘤中 CD10 的启动子 DNA 甲基化。
DOI：
10.1038/sj.leu.2404353
复制
发表时间：
2006
期刊：
影响因子：
11.4
通讯作者：
Caldwell,CW
中科院分区：
文献类型：
--
作者：
Taylor,KH;Liu,J;Guo,J;Davis,JW;Shi,H;Caldwell,CW
B系细胞的造血是一个复杂的过程，需要有助于发育和功能的多种表面和细胞质蛋白的阶段特异性表达。这个复杂的过程包括从淋巴祖细胞到终末分化浆细胞的生物学进展。正常生物学进程中的每一步都有一个恶性对应物，称为白血病或淋巴瘤（图1a和B）。中性内肽酶24.11（NEP或CD 10）被认为是B细胞生长和增殖的调节剂。2该酶是一种细胞表面氨肽酶，能够降解许多具有各种功能的生物活性肽，这些功能取决于细胞类型或来源组织，并且在早期骨髓（BM）前体B细胞和淋巴结生发中心（GC）B细胞中具有活性。此外，CD 10在恶性肿瘤中表达，包括前体B细胞急性淋巴细胞白血病（B-ALL）、GC相关的非霍奇金淋巴瘤（NHL）如伯基特淋巴瘤和滤泡性淋巴瘤（FL）和GC相关的弥漫性大B细胞淋巴瘤（DLBCL）。然而，在多发性骨髓瘤（MM）的终末分化浆细胞、套细胞淋巴瘤（MCL）的前GC细胞或B细胞慢性淋巴细胞白血病（B-CLL）的前或后GC细胞中不表达。因此，在正常和肿瘤性B细胞和前体B细胞中，存在与特定发育阶段相关的CD 10细胞表面蛋白表达的双相模式（图1c）。
Lymphopoiesis of B-lineage cells is a complex process requiring stage-specific expression of multiple surface and cytoplasmic proteins that contribute to development and function. This complex process comprises biological progression from a lymphoid progenitor cell to a terminally differentiated plasma cell. Each step in this normal biological progression also has a malignant counterpart either referred to as leukemia or lymphoma (Figure 1a and b). 1 The neutral endopeptidase 24.11,(NEP or CD10), is considered a regulator of B-cell growth and proliferation. 2 The enzyme is a cell surface aminopeptidase capable of degrading a number of bioactive peptides with various functions that depend on the cell type or tissue of origin and is active in early bone marrow (BM) precursor B cells and lymph node germinal center (GC) B cells. In addition, CD10 is expressed in malignancies including precursor B cell acute lymphocytic leukemia (B-ALL), GC-related non-Hodgkin’s lymphoma (NHL) such as Burkitt’s lymphoma and follicular lymphoma (FL), and GC-related diffuse large B-cell lymphomas (DLBCL). It is not, however, expressed in terminally differentiated plasma cells of multiple myeloma (MM), in the pre-GC cells of mantle cell lymphoma (MCL), or in the pre-or post-GC cells of B-cell chronic lymphocytic leukemia (B-CLL). Thus, there is a biphasic pattern of CD10 cell surface protein expression that correlates with specific stages of development in both normal and neoplastic B cells and precursor B cells (Figure 1c).