Computation of group-level electric field in lower limb motor area for different tDCS montages
Computation of group-level electric field in lower limb motor area for different tDCS montages
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DOI：
10.1016/j.clinph.2023.03.009
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发表时间：
2023-04-04
影响因子：
4.7
通讯作者：
Hirata，Akimasa
中科院分区：
文献类型：
--
作者：
Hamajima，Hiroki;Gomez-Tames，Jose;Hirata，Akimasa
目的经颅直流电刺激（tDCS）通过连接在头皮上的电极向大脑内注入微弱电流，调节大脑皮层的兴奋性。tDCS用于在康复中平衡受影响和未受影响的大脑半球之间的大脑活动。然而，对下肢tDCS蒙太奇的系统定量评价尚未见报道。在这项研究中，我们使用高分辨率头部模型计算研究了产生的电场强度、极性和皮层区域的共同刺激，以达到下肢瞄准的目的。方法采用体积导体模型来估计脑内电场。采用18个健康受试者头部模型，计算tDCS 4个蒙太奇调制下肢产生的组水平电场。结果sc1 - c2蒙太奇在到达下肢运动区较深区域时，电场强度较高。它在同一半球目标上产生均匀的偏振，在半球之间具有可比较的强度，但具有较高的可变性。结论适当的蒙太奇选择可以使极化均匀地到达下肢运动区的深层区域。意义：首次系统计算研究，在考虑极性因素平衡脑活动的情况下，为使用蒙太奇进行下肢tDCS实验研究提供支持。
ObjectiveTranscranial direct current stimulation (tDCS) injects a weak electric current into the brain via electrodes attached to the scalp to modulate cortical excitability. tDCS is used to rebalance brain activity between affected and unaffected hemispheres in rehabilitation. However, a systematic quantitative evaluation of tDCS montage is not reported for the lower limbs. In this study, we computationally investigated the generated electric field intensity, polarity, and co-stimulation of cortical areas for lower limb targeting using high-resolution head models.MethodsVolume conductor models have thus been employed to estimate the electric field in the brain. A total of 18 head models of healthy subjects were used to calculate the group-level electric fields generated from four montages of tDCS for modulation of lower limbs.ResultsC1-C2 montage delivered higher electric field intensities while reaching deeper regions of the lower-limb motor area. It produced a uniform polarization on the same hemisphere target with comparable intensities between hemispheres but with higher variability.ConclusionsProper montage selection allows reaching deeper regions of the lower-limb motor area with uniform polarization.SignificanceFirst systematic computational study providing support to tDCS experimental studies using montages for the lower limb while considering polarity factor for balancing brain activity.