Contrast-enhanced power Doppler ultrasonography of the metacarpophalangeal joints in rheumatoid arthritis
Contrast-enhanced power Doppler ultrasonography of the metacarpophalangeal joints in rheumatoid arthritis
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DOI：
10.1007/s00330-002-1459-2
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发表时间：
2003-01-01
影响因子：
5.9
通讯作者：
Ostergaard, M
中科院分区：
文献类型：
--
作者：
Szkudlarek, M;Court-Payen, M;Ostergaard, M
The aim of this study was to examine, with dynamic contrast-enhanced MRI as the reference, if contrast-enhanced power Doppler ultrasonography (CE PDUS) of rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints provides additional information for evaluation of synovial inflammation compared with PDUS. One MCP joint in each of 15 RA patients and 3 healthy control persons were examined with PDUS before and after intravenous bolus Levovist contrast injection. Corresponding rates of early synovial enhancement (RESE), previously shown to be closely related to histopathological synovitis, were calculated from dynamic contrast-enhanced MR images obtained the same day. Prior to ultrasonography, the joint was evaluated clinically. Levovist increased the flow signal in 7 of 9 joints with pre-contrast flow-signal and in 0 of 9 without pre-contrast signal. No healthy controls showed CE PDUS signal. The results of CE PDUS and dynamic MRI were closely related: RESE in joints with CE PDUS signal was significantly higher than in joints without CE PDUS signal (Mann-Whitney test, p
