Recent Developments in Dynamic Kinetic Resolution
Recent Developments in Dynamic Kinetic Resolution
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DOI：
10.1002/chin.201141224
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发表时间：
2008-02
期刊：
影响因子：
--
通讯作者：
H. Pellissier
中科院分区：
文献类型：
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作者：
H. Pellissier
本综述旨在更新用于通过酶法或非酶法获得DKR的主要技术，并说明通过这一强大的概念可以获得的有用产品的多样性，涵盖2008年至2010年的文献。立体异构体的拆分一直是获得对映体纯化合物的可靠方法，但收率仅为50%的基本限制使其彻底过时。DKR的使用似乎正在增加，并且这些策略似乎已成为不对称合成的常规方法的重要替代品。在过去两年中，DKR的应用效率和范围都有了重大发展。事实上，令人印象深刻的例子，使用新的酶和重大进展的DKR的外消旋体已经发生在过去几年。酶催化和金属催化的强有力结合也是引人注目的发展主题。此外，在过去几年中出现了一种基于使用有机催化剂的新型DKR，提供了越来越多的出版物。下载全尺寸图像下载为PowerPoint幻灯片
This review is intended to update the principal techniques used to obtain DKR by either enzymatic or non-enzymatic methods and illustrates the diversity of useful products that can be obtained through this powerful concept, covering the literature from 2008 to 2010. The resolution of stereoisomers has always been a reliable method of obtaining enantiomerically pure compounds, but the fundamental limitation of the yield to 50% has made it thoroughly unfashionable. The use of DKR seems to be increasing and it appears that these strategies have become serious alternatives to conventional methods for asymmetric synthesis. The last two years have witnessed significant developments in the efficiency and scope of the application of DKR. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzyme catalysis and metal catalysis has also been the subject of spectacular development. In addition, a new type of DKR based on the use of organocatalysts has appeared in the last few years, providing an increasing number of publications. Figure options Download full-size image Download as PowerPoint slide