Human skeletal muscle fiber type adaptability to various workloads.
Human skeletal muscle fiber type adaptability to various workloads.
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人体骨骼肌纤维类型对各种工作负载的适应性。
DOI：
10.1177/32.2.6229571
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
T. Murray
中科院分区：
文献类型：
--
作者：
R. Staron;R. S. Hikida;F. Hagerman;G. Dudley;T. Murray
从三组人类受试者的股外侧肌中取出肌肉活检标本：对照组、举重运动员和长跑运动员。跑步者被证明是一个独特的群体，相对于测量的变量（低体重和体脂百分比，高VO2最大值）。此外，对活检标本的组织化学分析显示，跑步者的I型和IIC型纤维的百分比明显高于对照组或举重者。使用冷冻修复方法，然后使用电子显微镜进行形态计量学分析，组织化学鉴定的每种纤维。体积百分比线粒体的结果表明，ATP酶活性和氧化电位的纤维类型的所有三个组，这样的氧化活性将被评为I大于IIA大于IIB之间的强关系。无论纤维类型，有组之间的肌肉纤维线粒体（跑步者大于举重者大于对照组）和脂质含量（跑步者大于对照组大于举重者）的显着差异。举重运动员的线粒体含量明显高于对照组，这可能表明不活动而不是举重运动导致线粒体体积百分比低和IIB型纤维百分比高。
Muscle biopsy specimens were removed from the vastus lateralis muscles of three groups of human subjects: controls, weight lifters, and distance runners. The runners proved to be a unique group with respect to the variables measured (low body weight and percentage body fat, and high VO2 max). Additionally, a histochemical analysis of the biopsy specimens revealed that the runners had a significantly higher percentage of fiber types I and IIC than either the controls or the weight lifters. Using a cryostatic retrieval method, each of the fibers identified histochemically was then analyzed morphometrically using electron microscopy. The results of volume-percent mitochondria demonstrated a strong relationship between the ATPase activity and oxidative potential of the fiber types for all three groups such that the oxidative activity would be ranked I greater than IIA greater than IIB. Irrespective of fiber type, there were significant differences between the groups with regard to muscle-fiber mitochondrial (runners greater than lifters greater than controls) and lipid content (runners greater than controls greater than lifters). The lifters had a significantly greater content of mitochondria than the controls, which may suggest that inactivity rather than the lifting exercise contributes to a low volume-percent mitochondria and a high percentage of type IIB fibers.