Mixed Ligand Complexes of N-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand.
Mixed Ligand Complexes of N-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand.
复制标题
DOI：
10.1155/2015/913424
复制
发表时间：
2015
影响因子：
3.8
通讯作者：
Ebenso EE
中科院分区：
文献类型：
--
作者：
Ekennia AC;Onwudiwe DC;Ume C;Ebenso EE
合成了一系列二硫代氨基甲酸混配配合物[ML_2（py）_2]，其中M = Mn（II），Co（II），Ni（II），Cu（II），py =吡啶，L = N-甲基-N-苯基二硫代氨基甲酸酯，并通过元素分析、红外光谱、紫外光谱、磁矩、热重分析和电导分析对其进行了表征。红外光谱表明，配合物中吡啶分子通过硫原子与二硫代氨基甲酸酯发生对称的双齿配位，而通过氮原子发生中性的单齿配位.电子光谱、元素分析和磁矩结果证明配合物为八面体构型。电导测量表明，配合物是非电解质证明其非离子性质。对三种人类致病真菌：黄曲霉、尼日尔曲霉和白色念珠菌筛选化合物。其中钴配合物的抗真菌活性最好。研究了配体在不同溶剂介质中对铜、镍离子的液-液萃取能力。配体对金属离子表现出很强的结合亲和力，萃取效率约为99%。
A series of mixed ligand dithiocarbamate complexes with a general formula [ML2(py)2], where M = Mn(II), Co(II), Ni(II), and Cu(II), py = pyridine, and L = N-methyl-N-phenyl dithiocarbamate have been prepared and characterised by elemental analysis, FTIR and Uv spectroscopy, magnetic moment, and thermogravimetric and conductance analysis. The infrared spectra showed that symmetrical bidentate coordination occurred with the dithiocarbamate moiety through the sulfur atoms, while neutral monodentate coordination occurred through the nitrogen atom for the pyridine molecule in the complexes. The electronic spectra, elemental analysis, and magnetic moment results proved that the complexes adopted octahedral geometry. The conductance measurement showed that the complexes are nonelectrolytes proving their nonionic nature. The compounds were screened for three human pathogenic fungi: Aspergillus flavus, Aspergillus niger, and Candida albicans. The cobalt complex showed the best antifungal activity among the test compounds. Liquid-liquid extractive abilities of the ligand towards copper and nickel ions in different solvent media were investigated. The ligand showed a strong binding affinity towards the metals ions with an extractive efficiency of about 99%.