Multicentric Osteosarcoma, Rothmund‐Thomson Syndrome, and Secondary Nasopharyngeal Non‐Hodgkin's Lymphoma: A Case Report and Review of the Literature
Multicentric Osteosarcoma, Rothmund‐Thomson Syndrome, and Secondary Nasopharyngeal Non‐Hodgkin's Lymphoma: A Case Report and Review of the Literature
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多中心骨肉瘤、罗斯蒙德-汤姆森综合征和继发性鼻咽非霍奇金淋巴瘤：病例报告及文献复习
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Huvos
中科院分区：
文献类型：
--
作者：
Christopher Spurney;R. Gorlick;P. Meyers;J. Healey;A. Huvos
目的：Rothmund-Thomson综合征(RTS)是一种以白斑为特征的常染色体隐性遗传病。感光性。骨骼畸形和其他变化。它还与包括骨肉瘤在内的恶性肿瘤风险增加有关。已报道了16例RTS和骨肉瘤。患者：描述了一例多中心性骨肉瘤发生的RTS患者。手术和化疗后，继发性恶性肿瘤(SMN)的发展与鼻咽部非霍奇金淋巴瘤一致。结果：患者经Anli-CD20单抗治疗后完全缓解。结论：这是第一例因骨肉瘤而发生SMN的RTS患者的报告。这种SMN的潜在因素包括遗传易感性和既往化疗。
Purpose: Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma. photosensitivity. skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported. Patient: A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma. Results: The patient was treated with anli-CD20 monoclonal antibody and is in complete remission. Conclusion: This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.
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影响因子：
45.3
作者：
Meyers, PA;Gorlick, R;Healey, JH
通讯作者：
Healey, JH
影响因子：
56.9
作者：
MALKIN, D;LI, FP;FRIEND, SH
通讯作者：
FRIEND, SH
DOI：
10.1002/mpo.2950220102
发表时间：
1994
期刊：
Medical and pediatric oncology
影响因子：
--
作者：
D. M. Green;M. Zevon;P. Reese;G. S. Lowrie;J. Gaeta;J. Pearce;A. Michalek;E. A. Stephens
通讯作者：
D. M. Green;M. Zevon;P. Reese;G. S. Lowrie;J. Gaeta;J. Pearce;A. Michalek;E. A. Stephens
儿童软组织肉瘤幸存者及其亲属的癌症。
DOI：
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发表时间：
1987
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Strong,LC;Stine,M;Norsted,TL
通讯作者：
Norsted,TL