Decreased levels of circulating IFN-alpha and increased sCD23 in patients with acute infectious mononucleosis
Decreased levels of circulating IFN-alpha and increased sCD23 in patients with acute infectious mononucleosis
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DOI：
10.1089/vim.1996.9.45
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发表时间：
1996-01-01
期刊：
影响因子：
2.2
通讯作者：
Mathur, A
中科院分区：
文献类型：
--
作者：
Prabhu, A;Warwick, M;Mathur, A
EB病毒（Epstein-Barr virus，EBV）是急性传染性单核细胞增多症（acute infectious mononucleosis，AIM）的病原。它还与免疫缺陷个体的某些恶性疾病如B细胞淋巴增生性疾病（BLPD）相关。我们之前对BLPD患者的研究表明，血清IL-4和IgE水平显著升高，IFN-α水平显著降低。这些观察结果与T细胞衍生的细胞因子调节B细胞生长的模型一致，其中IL-4促进B细胞生长并转换为IgE合成，而IFN-α和IFN-γ抑制这些IL-4介导的作用。由于AIM也与EBV相关，因此本研究旨在检查AIM患者的IL-4、IFN-α、IFN-γ、IgE和可溶性CD 23（sCD 23）血清水平。在这项研究中，我们首次报告，与BLPD患者相比，AIM患者没有表现出IL-4和IgE水平升高;然而，AIM患者确实表现出IFN-α水平降低，此外，还表现出显著更高的sCD 23水平。这可能导致B细胞活化，并影响病毒在B细胞中的存活。
Epstein-Barr virus (EBV) is the etiological agent for acute infectious mononucleosis (AIM). It is also associated with certain malignant disorders in individuals with immunodeficiencies such as B cell lymphoproliferative disorder (BLPD). Our previous study with BLPD patients had demonstrated significantly higher serum IL-4 and IgE levels and significantly decreased IFN-alpha levels. These observations were consistent with the model of regulation of B cell growth by T cell-derived cytokines, in which IL-4 promotes B cell growth and switch to IgE synthesis whereas IFN-alpha and IFN-gamma inhibit these IL-4-mediated effects. Since AIM is also EBV associated, this study was designed to examine IL-4, IFN-alpha, IFN-gamma, IgE, and soluble CD23 (sCD23) serum levels in AIM patients. In this study we report for the first time that in contrast to BLPD patients, AIM patients did not exhibit increased levels of IL-4 and IgE; however AIM patients do exhibit decreased IFN-alpha levels and, additionally, also exhibit significantly higher sCD23 levels. This could result in B cell activation and have implications for the survival of the virus in B cells.