The prevalence of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus) increases with the duration of captivity
The prevalence of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus) increases with the duration of captivity
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DOI：
10.3109/00016349609033298
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发表时间：
1996-02-01
影响因子：
4.3
通讯作者：
Koninckx, PR
中科院分区：
文献类型：
--
作者：
DHooghe, TM;Bambra, CS;Koninckx, PR
背景资料。目前尚不清楚压力是否会影响女性子宫内膜异位症的患病率。患有自发性子宫内膜异位症的狒狒可能是研究人类疾病的有趣模型。为狒狒准备的。圈养是一段没有持续妊娠暴露的慢性应激期，本研究比较了最近在野外捕获的和圈养了几年的狒狒子宫内膜异位症的患病率。应用诊断性腹腔镜对104只雌性狒狒进行子宫内膜异位症的筛查和活检，其中包括不到1年前在野外捕获的动物(n=52，I组)、圈养1~2年的灵长类动物(n=30)。II组)和捕获2年以上的动物(n=22，III组)。临床和活检证实的子宫内膜异位症在所有狒狒中的患病率分别为17%和12%。临床子宫内膜异位症的发生率，III组(32%)高于II组(17%)或I组(11%)。经活检证实的子宫内膜异位症的患病率，III组(27%)显著高于I组和II组(8%，p=0.03)。结果表明，随着圈养时间的延长，子宫内膜异位症的患病率增加，这一趋势可能是圈养的比野生的狒狒有更多的未被妊娠中断的月经周期所致。也可能是由于与年龄有关的因素或与囚禁相关的压力。
Background. It is nor known whether stress affects the prevalence of endometriosis in women. Baboons with spontaneous endometriosis may be interesting models to study the human disease. For baboons. living in captivity is a period of chronic stress without continuous exposure to pregnancy This study was done to compare the prevalence of endometriosis between baboons recently captured in the wild and those living in captivity for several years.Methods. A diagnostic laparoscopy was performed for screening endometriosis and obtaining biopsies in 104 female baboons including animals that had been captured in the wild less than 1 year ago (n=52, Group I), primates that had been living in captivity for one to two years (n=30. Group II) and animals that had been captured for more than two years (n=22, Group III).Results. The prevalence of clinical and biopsy-proven endometriosis in all baboons was 17% and 12%, respectively. Clinical endometriosis was found more frequently in group III (32%) than in group II (17%) or group I (11%). The prevalence of biopsy-proven endometriosis was also significantly higher in group III (27%) than in groups I and II combined (8%, p=0.03).Conclusions. The results indicate that the prevalence of endometriosis increases with the time spent in captivity This trend may be explained by more menstrual cycles uninterrupted by pregnancy in captive than in wild baboons. and possibly also by age-related factors or by captivity-associated stress.