Studies on Replacement and Suppressive Dosages of l-Thyroxine
Studies on Replacement and Suppressive Dosages of l-Thyroxine
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L-甲状腺素替代和抑制剂量的研究
DOI：
10.1111/j.0954-6820.1977.tb16823.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Hughes
中科院分区：
文献类型：
--
作者：
G. Nilsson;U. Pettersson;K. Levin;R. Hughes
本文对55例甲状腺功能减退症患者的血清促甲状腺激素（TSH）水平进行了测定，以确定1-甲状腺素（T_4）的适当替代和抑制剂量。根据以前的报告，发现大多数患者的TSH水平正常，并且在每日剂量为0.10-0.15 mg T4时临床甲状腺功能正常。没有患者需要超过0.20 mg的剂量。当TSH水平恢复正常时，血清甲状腺素和血清三碘甲状腺原氨酸也降至正常范围内。在57例用T4治疗的无毒性甲状腺肿或甲状腺次全切除术后的患者中，检测了不同剂量T4抑制促甲状腺素释放激素正常诱导的血清TSH浓度暂时升高的有效性。TSH的升高通常不受小于0.20 mg T4剂量的抑制，这一发现至少在理论上对T4的适当抑制剂量有影响。
: Serum thyrotropin (TSH) levels were studied in 55 hypothyroid patients in order to determine adequate replacement and suppression dosages of 1-thyroxine (T4). In accordance with previous reports it was found that most patients had normal TSH levels and were clinically euthyroid at daily doses of 0.10-0.15 mg T4. None of the patients required a dose exceeding 0.20 mg. When the TSH levels normalized, serum thyroxine and serum triiodothyronine also fell to levels within their normal ranges. The effectiveness of various doses of T4 in suppressing the temporary rise in serum TSH concentration normally induced by thyrotropin-releasing hormone was examined in 57 patients treated with T4 for atoxic goitre or after subtotal surgical removal of such a goitre. The rise in TSH was not usually inhibited by a T4 dose of less than 0.20 mg, a finding which at least theoretically has implications for the adequate suppressive dose of T4.